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GLOSSARY & ABBREVIATIONS

Homopro

L-Homoprolyl (L-Pipecoloyl; (S)-Piperidine-2-carbonyl)

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L-Homoproline or L-pipecolic acid, also abbreviated Pip or Hpr. The proline homolog Hpr is a degradation product of L-lysine. Both enantiomers can be detected in human plasma.
As proline residues strongly influence the conformation of a peptide, replacement of Pro by Hpr (or azetidine-2-carboxylic acid (Aze)) can modulate its secondary structure.

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