Bradykinin Acetate 50 µg/vial (Clinalfa basic)


A considerable number of publications on Clinalfa products used in clinical trials are available. The most important publications are listed below. For a comprehensive list please contact us.


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Literature references citing the Clinalfa basic product


Ozkor, M. A., Murrow, J. R., Rahman, A. M., Kavtaradze, N., Lin, J., Manatunga, A. and Quyyumi, A. A.
Endothelium-derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease.
Circulation 123, 2244-2253 (2011)



Pretorius, M. and Brown, N. J.
Endogenous nitric oxide contributes to bradykinin-stimulated glucose uptake but attenuates vascular tissue-type plasminogen activator release.
J. Pharmacol. Exp. Ther. 332, 291-297 (2010)



Gunaruwan, P., Maher, A., Williams, L., Sharman, J., Schmitt, M., Campbell, R. and Frenneaux, M.
Effects of bradykinin on venous capacitance in health and treated chronic heart failure.
Clin. Sci. (Lond) 116, 443-450 (2009)



Dias, M. P., Newton, D. J., McLeod, G. A., Khan, F. and Belch, J. J.
The inhibitory effects of local anaesthetics on the vascular flare responses to bradykinin and substance P in human skin.
Anaesthesia 63, 151-155 (2008)

Lang, N. N., Gudmundsdottir, I. J., Boon, N. A., Ludlam, C. A., Fox, K. A. and Newby, D. E.
Marked impairment of protease-activated receptor type 1-mediated vasodilation and fibrinolysis in cigarette smokers: smoking, thrombin, and vascular responses in vivo.
J. Am. Coll. Cardiol. 52, 33-39 (2008)

Van Guilder, G. P., Stauffer, B. L., Greiner, J. J. and Desouza, C. A.
Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists.
Am. J. Physiol. Heart Circ. Physiol. 294, H1685-1692 (2008)



Mills, N. L., Tornqvist, H., Gonzalez, M. C., Vink, E., Robinson, S. D., Soderberg, S., Boon, N. A., Donaldson, K., Sandstrom, T., Blomberg, A. and Newby, D. E.
Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease.
N. Engl. J. Med. 357, 1075-1082 (2007)



Battaglia, S., Angus, P. and Chin-Dusting, J. P.
Role of the endothelium on vasoactive agents in patients with liver cirrhosis.
J. Gastroenterol. Hepatol. 21, 1189-1193 (2006)

Helmy, A., Ferguson, J. W., Hayes, P. C., Newby, D. E. and Webb, D. J.
Bradykinin does not contribute to peripheral vascular tone in patients with cirrhosis and ascites.
J. Cardiovasc. Pharmacol. 47, 556-560 (2006)

Murphey, L. J., Malave, H. A., Petro, J., Biaggioni, I., Byrne, D. W., Vaughan, D. E., Luther, J. M., Pretorius, M. and Brown, N. J.
Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans.
J. Pharmacol. Exp. Ther. 318, 1287-1292 (2006)



Kamper, A. M., de Craen, A. J., Westendorp, R. G. and Blauw, G. J.
Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral alpa1-adrenoceptor activation.
Vasc. Health Risk Manag. 1, 251-256 (2005)

Schrage, W. G., Dietz, N. M., Eisenach, J. H. and Joyner, M. J.
Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle.
J. Appl. Physiol. 98, 1251-1257 (2005)



Clapp, B. R., Hingorani, A. D., Kharbanda, R. K., Mohamed-Ali, V., Stephens, J. W., Vallance, P. and MacAllister, R. J.
Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.
Cardiovasc. Res. 64, 172-178 (2004)

Cruden, N. L., Fox, K. A., Ludlam, C. A., Johnston, N. R. and Newby, D. E.
Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition.
Hypertension 44, 913-918 (2004)

Cruden, N. L., Witherow, F. N., Webb, D. J., Fox, K. A. and Newby, D. E.
Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.
Arterioscler. Thromb. Vasc. Biol. 24, 1043-1048 (2004)



Chan, N. N., Fuller, J. H., Rubens, M. and Colhoun, H. M.
Von Willebrand factor in type 1 diabetes: its production and coronary artery calcification.
Med. Sci. Monit. 9, CR297-303 (2003)

Chia, S., Ludlam, C. A., Fox, K. A. and Newby, D. E.
Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men.
J. Am. Coll. Cardiol. 41, 333-339 (2003)

Grahame-Clarke, C., Chan, N. N., Andrew, D., Ridgway, G. L., Betteridge, D. J., Emery, V., Colhoun, H. M. and Vallance, P.
Human cytomegalovirus seropositivity is associated with impaired vascular function.
Circulation 108, 678-683 (2003)

Guthikonda, S., Sinkey, C., Barenz, T. and Haynes, W. G.
Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers.
Circulation 107, 416-421 (2003)

Hoetzer, G. L., Stauffer, B. L., Greiner, J. J., Casas, Y., Smith, D. T. and DeSouza, C. A.
Influence of oral contraceptive use on endothelial t-PA release in healthy premenopausal women.
Am. J. Physiol. Endocrinol. Metab. 284, E90-95 (2003)

Kemme, M. J., Burggraaf, J., Schoemaker, R. C., Cohen, A. F., Kluft, C., Chia, S., Webb, D. J. and Newby, D. E.
Local tissue factor pathway inhibitor release in the human forearm.
Thromb. Haemost. 89, 438-445 (2003)

Lauer, T., Kleinbongard, P., Preik, M., Rauch, B. H., Deussen, A., Feelisch, M., Strauer, B. E. and Kelm, M.
Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculature.
Basic. Res. Cardiol. 98, 84-89 (2003)

Mork, H., Ashina, M., Bendtsen, L., Olesen, J. and Jensen, R.
Experimental muscle pain and tenderness following infusion of endogenous substances in humans.
Eur. J. Pain 7, 145-153 (2003)

Passauer, J., Bussemaker, E., Lassig, G., Pistrosch, F., Fauler, J., Gross, P. and Fleming, I.
Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole.
Clin. Sci. (Lond) 105, 513-518 (2003)

Pretorius, M., Rosenbaum, D., Vaughan, D. E. and Brown, N. J.
Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin.
Circulation 107, 579-585 (2003)

Schram, M. T., Stam, F., de Jongh, R. T., de Vries, G., van Dijk, R. A., Serne, E. H., Lampe, D., Nanayakkara, P. W., Tushuizen, M. E., Scheffer, P. G., Schalkwijk, C. G., Kamper, A. M. and Stehouwer, C. D.
The effect of calcium dobesilate on vascular endothelial function, blood pressure, and markers of oxidation in obese male smokers: a placebo-controlled randomised clinical trial.
Atherosclerosis 170, 59-72 (2003)

Smith, D. T., Hoetzer, G. L., Greiner, J. J., Stauffer, B. L. and DeSouza, C. A.
Endothelial release of tissue-type plasminogen activator in the human forearm: role of nitric oxide.
J. Cardiovasc. Pharmacol. 42, 311-314 (2003)

Taddei, S., Virdis, A., Ghiadoni, L., Versari, D., Salvetti, G., Magagna, A. and Salvetti, A.
Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension.
Hypertension 41, 950-955 (2003)

Vigili de Kreutzenberg, S., Kiwanuka, E., Tiengo, A. and Avogaro, A.
Visceral obesity is characterized by impaired nitric oxide-independent vasodilation.
Eur. Heart J. 24, 1210-1215 (2003)



Chan, N. N., Vallance, P., Colhoun, H. M., MacAllister, R. J., Hingorani, A. D. and Conway, G. S.
The effects of hormone replacement therapy on endothelial function in women with Turner's syndrome.
Clin. Endocrinol. (Oxf) 56, 615-620 (2002)

Davie, A. P. and McMurray, J. J.
Effect of aspirin on vasodilation to bradykinin and substance P in patients with heart failure treated with ACE inhibitor.
Br. J. Clin. Pharmacol. 53, 37-42 (2002)

DeSouza, C. A., Clevenger, C. M., Greiner, J. J., Smith, D. T., Hoetzer, G. L., Shapiro, L. F. and Stauffer, B. L.
Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humans.
J. Physiol. 542, 255-262 (2002)

Kharbanda, R. K., Walton, B., Allen, M., Klein, N., Hingorani, A. D., MacAllister, R. J. and Vallance, P.
Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin.
Circulation 105, 2600-2604 (2002)

Pretorius, M., Rosenbaum, D. A., Lefebvre, J., Vaughan, D. E. and Brown, N. J.
Smoking impairs bradykinin-stimulated t-PA release.
Hypertension 39, 767-771 (2002)

Singh, N., Graves, J., Taylor, P. D., MacAllister, R. J. and Singer, D. R.
Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects.
Cardiovasc. Res. 56, 118-125 (2002)

Witherow, F. N., Dawson, P., Ludlam, C. A., Fox, K. A. and Newby, D. E.
Marked bradykinin-induced tissue plasminogen activator release in patients with heart failure maintained on long-term angiotensin-converting enzyme inhibitor therapy.
J. Am. Coll. Cardiol. 40, 961-966 (2002)



Ceballos, C., Ribes, C., Amado, J. A., de Mier, I., de Rozas, L. S. and Berrazueta, J. R.
Venous endothelial function in postmenopausal women after six months of tibolone therapy.
Maturitas 39, 63-70 (2001)

Chan, N. N., Colhoun, H. M. and Vallance, P.
Cardiovascular risk factors as determinants of endothelium-dependent and endothelium-independent vascular reactivity in the general population.
J. Am. Coll. Cardiol. 38, 1814-1820 (2001)

Chan, N. N., MacAllister, R. J., Colhoun, H. M., Vallance, P. and Hingorani, A. D.
Changes in endothelium-dependent vasodilatation and alpha-adrenergic responses in resistance vessels during the menstrual cycle in healthy women.
J. Clin. Endocrinol. Metab. 86, 2499-2504 (2001)

Clive, S., Webb, D. J., MacLellan, A., Young, A., Byrne, B., Robson, L., Smyth, J. F. and Jodrell, D. I.
Forearm blood flow and local responses to peptide vasodilators: a novel pharmacodynamic measure in the phase I trial of antagonist G, a neuropeptide growth factor antagonist.
Clin. Cancer. Res. 7, 3071-3078 (2001)

Labinjoh, C., Newby, D. E., Pellegrini, M. P., Johnston, N. R., Boon, N. A. and Webb, D. J.
Potentiation of bradykinin-induced tissue plasminogen activator release by angiotensin-converting enzyme inhibition.
J. Am. Coll. Cardiol. 38, 1402-1408 (2001)

Raghuveer, G., Sinkey, C. A., Chenard, C., Stumbo, P. and Haynes, W. G.
Effect of vitamin E on resistance vessel endothelial dysfunction induced by methionine.
Am. J. Cardiol. 88, 285-290 (2001)

Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., Pasini, A. F., Garbin, U., Cominacini, L. and Salvetti, A.
Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients.
J. Hypertens. 19, 1379-1386 (2001)

Witherow, F. N., Helmy, A., Webb, D. J., Fox, K. A. and Newby, D. E.
Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.
Circulation 104, 2177-2181 (2001)



Aptecar, E., Teiger, E., Dupouy, P., Benvenuti, C., Kern, M. J., Woscoboinik, J., Sediame, S., Pernes, J. M., Castaigne, A., Loisance, D. and Dubois-Rande, J. L.
Effects of bradykinin on coronary blood flow and vasomotion in transplant patients.
J. Am. Coll. Cardiol. 35, 1607-1615 (2000)

Babenko, V., Svensson, P., Graven-Nielsen, T., Drewes, A. M., Jensen, T. S. and Arendt-Nielsen, L.
Duration and distribution of experimental muscle hyperalgesia in humans following combined infusions of serotonin and bradykinin.
Brain Res. 853, 275-281 (2000)

Ceballos, C., Ribes, C., Amado, J. A., Perez, J., Garcia Unzueta, M. T. and de Berrazueta, J. R.
Venous endothelial function in postmenopausal women who are receiving long-term estrogen and progestagen therapy.
Fertil. Steril. 74, 268-273 (2000)

Frossard, M., Joukhadar, C., Steffen, G., Schmid, R., Eichler, H. G. and Muller, M.
Paracrine effects of angiotensin-converting-enzyme- and angiotensin-II-receptor- inhibition on transcapillary glucose transport in humans.
Life Sci. 66, PL147-154 (2000)

Hingorani, A. D., Cross, J., Kharbanda, R. K., Mullen, M. J., Bhagat, K., Taylor, M., Donald, A. E., Palacios, M., Griffin, G. E., Deanfield, J. E., MacAllister, R. J. and Vallance, P.
Acute systemic inflammation impairs endothelium-dependent dilatation in humans.
Circulation 102, 994-999 (2000)

Honing, M. L., Smits, P., Morrison, P. J. and Rabelink, T. J.
Bradykinin-induced vasodilation of human forearm resistance vessels is primarily mediated by endothelium-dependent hyperpolarization.
Hypertension 35, 1314-1318 (2000)

Kimura, M., Watanabe, H., Takahashi, R., Kosuge, K., Umemura, K., Hayashi, H., Ohashi, K. and Ohno, R.
Inhibitory effect of insulin on bradykinin-induced venodilation.
J. Hypertens. 18, 287-292 (2000)

Labinjoh, C., Newby, D. E., Dawson, P., Johnston, N. R., Ludlam, C. A., Boon, N. A. and Webb, D. J.
Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man.
Cardiovasc. Res. 47, 707-714 (2000)

Sabha, M., Tanus-Santos, J. E., Toledo, J. C., Cittadino, M., Rocha, J. C. and Moreno, H., Jr.
Transdermal nicotine mimics the smoking-induced endothelial dysfunction.
Clin. Pharmacol. Ther. 68, 167-174 (2000)

van Dijk, M. A., Kroon, I., Kamper, A. M., Boomsma, F., Danser, A. H. and Chang, P. C.
The angiotensin-converting enzyme gene polymorphism and responses to angiotensins and bradykinin in the human forearm.
J. Cardiovasc. Pharmacol. 35, 484-490 (2000)



Babenko, V., Graven-Nielsen, T., Svensson, P., Drewes, A. M., Jensen, T. S. and Arendt-Nielsen, L.
Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin.
Pain 82, 1-8 (1999)

Babenko, V. V., Graven-Nielsen, T., Svensson, P., Drewes, A. M., Jensen, T. S. and Arendt-Nielsen, L.
Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P.
Eur. J. Pain 3, 93-102 (1999)

Barba, G., Mullen, M. J., Donald, A. and MacAllister, R. J.
Determinants of the response of human blood vessels to nitric oxide donors in vivo.
J. Pharmacol. Exp. Ther. 289, 1662-1668 (1999)

Clough, G. F.
Role of nitric oxide in the regulation of microvascular perfusion in human skin in vivo.
J. Physiol. 516 ( Pt 2), 549-557 (1999)

Davie, A. P., Dargie, H. J. and McMurray, J. J.
Role of bradykinin in the vasodilator effects of losartan and enalapril in patients with heart failure.
Circulation 100, 268-273 (1999)

Davie, A. P. and McMurray, J. J.
Effect of angiotensin-(1-7) and bradykinin in patients with heart failure treated with an ACE inhibitor.
Hypertension 34, 457-460 (1999)

Gaspardone, A., Crea, F., Tomai, F., Versaci, F., Pellegrino, A., Chiariello, L. and Gioffre, P. A.
Effect of acetylsalicylate on cardiac and muscular pain induced by intracoronary and intra-arterial infusion of bradykinin in humans.
J. Am. Coll. Cardiol. 34, 216-222 (1999)

Taddei, S., Ghiadoni, L., Virdis, A., Buralli, S. and Salvetti, A.
Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients.
Circulation 100, 1400-1405 (1999)

Wilson, D. G., Bellamy, M. F., Ramsey, M. W., Goodfellow, J., Brownlee, M., Davies, S., Wilson, J. F., Lewis, M. J. and Stuart, A. G.
Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation.
Circulation 99, 909-915 (1999)



Taddei, S., Virdis, A., Ghiadoni, L., Mattei, P. and Salvetti, A.
Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients.
J. Hypertens. 16, 447-456 (1998)

Wenzel, R. R., Zbinden, S., Noll, G., Meier, B. and Luscher, T. F.
Endothelin-1 induces vasodilation in human skin by nociceptor fibres and release of nitric oxide.
Br. J. Clin. Pharmacol. 45, 441-446 (1998)



Haefeli, W. E., Linder, L. and Luscher, T. F.
Quinaprilat induces arterial vasodilation mediated by nitric oxide in humans.
Hypertension 30, 912-917 (1997)

Kuga, T., Mohri, M., Egashira, K., Hirakawa, Y., Tagawa, T., Shimokawa, H. and Takeshita, A.
Bradykinin-induced vasodilation of human coronary arteries in vivo: role of nitric oxide and angiotensin-converting enzyme.
J. Am. Coll. Cardiol. 30, 108-112 (1997)

Newby, D. E., Masumori, S., Johnston, N. R., Boon, N. A. and Webb, D. J.
Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man.
Cardiovasc. Res. 36, 268-275 (1997)

Taddei, S., Virdis, A., Ghiadoni, L., Uleri, S., Magagna, A. and Salvetti, A.
Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients.
Hypertension 30, 1606-1612 (1997)



Bhagat, K., Moss, R., Collier, J. and Vallance, P.
Endothelial "stunning" following a brief exposure to endotoxin: a mechanism to link infection and infarction?
Cardiovasc. Res. 32, 822-829 (1996)

Chadwick, I. G., Kraskiewicz, M., Yeo, W. W., Higgins, K. S., Jackson, P. R. and Ramsay, L. E.
No relation between angiotensin-converting enzyme gene polymorphism and dermal response to bradykinin in healthy subjects.
Clin. Sci. (Lond) 91, 617-620 (1996)

Dear, J. W., Ghali, S. and Foreman, J. C.
Attenuation of human nasal airway responses to bradykinin and histamine by inhibitors of nitric oxide synthase.
Br. J. Pharmacol. 118, 1177-1182 (1996)

Strobel, W. M., Luscher, T. F., Simper, D., Linder, L. and Haefeli, W. E.
Substance P in human hand veins in vivo: tolerance, efficacy, potency, and mechanism of venodilator action.
Clin. Pharmacol. Ther. 60, 435-443 (1996)



Kindgen-Milles, D.
Effects of prostaglandin E2 on the intensity of bradykinin-evoked pain from skin and veins of humans.
Eur. J. Pharmacol. 294, 491-496 (1995)



Cockcroft, J. R., Chowienczyk, P. J., Brett, S. E. and Ritter, J. M.
Effect of NG-monomethyl-L-arginine on kinin-induced vasodilation in the human forearm.
Br. J. Clin. Pharmacol. 38, 307-310 (1994)

Kindgen-Milles, D., Klement, W. and Arndt, J. O.
The nociceptive systems of skin, paravascular tissue and hand veins of humans and their sensitivity to bradykinin.
Neurosci. Lett. 181, 39-42 (1994)


Literature references citing the active pharmaceutical ingredient (API)


Matsumoto, T., Takashima, H., Ohira, N., Tarutani, Y., Yasuda, Y., Yamane, T., Matsuo, S. and Horie, M.
Plasma level of oxidized low-density lipoprotein is an independent determinant of coronary macrovasomotor and microvasomotor responses induced by bradykinin.
J. Am. Coll. Cardiol. 44, 451-457 (2004)

Wei, M., Wang, X., Kuukasjarvi, P., Laurikka, J., Rinne, T., Honkonen, E. L. and Tarkka, M.
Bradykinin preconditioning in coronary artery bypass grafting.
Ann. Thorac. Surg. 78, 492-497 (2004)



Brown, H., Moppett, I. K. and Mahajan, R. P.
Transient hyperaemic response to assess vascular reactivity of skin: effect of locally iontophoresed acetylcholine, bradykinin, epinephrine and phenylephrine.
Br. J. Anaesth. 90, 446-451 (2003)

de Kreutzenberg, S. V., Puato, M., Kiwanuka, E., Del Prato, S., Pauletto, P., Pasini, L., Tiengo, A. and Avogaro, A.
Elevated non-esterified fatty acids impair nitric oxide independent vasodilation, in humans: evidence for a role of inwardly rectifying potassium channels.
Atherosclerosis 169, 147-153 (2003)

Inokuchi, K., Hirooka, Y., Shimokawa, H., Sakai, K., Kishi, T., Ito, K., Kimura, Y. and Takeshita, A.
Role of endothelium-derived hyperpolarizing factor in human forearm circulation.
Hypertension 42, 919-924 (2003)

Matsumoto, T., Minai, K., Horie, H., Ohira, N., Takashima, H., Tarutani, Y., Yasuda, Y., Ozawa, T., Matsuo, S., Kinoshita, M. and Horie, M.
Angiotensin-converting enzyme inhibition but not angiotensin II type 1 receptor antagonism augments coronary release of tissue plasminogen activator in hypertensive patients.
J. Am. Coll. Cardiol. 41, 1373-1379 (2003)

Mork, H., Ashina, M., Bendtsen, L., Olesen, J. and Jensen, R.
Induction of prolonged tenderness in patients with tension-type headache by means of a new experimental model of myofascial pain.
Eur. J. Neurol. 10, 249-256 (2003)

Playford, D. A., Watts, G. F., Croft, K. D. and Burke, V.
Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes.
Atherosclerosis 168, 169-179 (2003)



Hirooka, K., Shiraga, F. and Hasegawa, E.
Bradykinin sensitivity in primary open-angle glaucoma and normal-tension glaucoma patients.
Am. J. Ophthalmol. 134, 922-924 (2002)

Rosenbaum, D. A., Pretorius, M., Gainer, J. V., Byrne, D., Murphey, L. J., Painter, C. A., Vaughan, D. E. and Brown, N. J.
Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin.
Arterioscler. Thromb. Vasc. Biol. 22, 1023-1028 (2002)

Yokohama, H., Matsumoto, T., Horie, H., Minai, K. and Kinoshita, M.
Coronary endothelium-dependent and independent vasomotor responses in patients with hypertrophic cardiomyopathy.
Circ. J. 66, 30-34 (2002)



Arcaro, G., Solini, A., Monauni, T., Cretti, A., Brunato, B., Lechi, A., Fellin, R., Caputo, M., Cocco, C., Bonora, E., Muggeo, M. and Bonadonna, R. C.
ACE genotype and endothelium-dependent vasodilation of conduit arteries and forearm microcirculation in humans.
Arterioscler. Thromb. Vasc. Biol. 21, 1313-1319 (2001)

Gainer, J. V., Stein, C. M., Neal, T., Vaughan, D. E. and Brown, N. J.
Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity.
Hypertension 37, 46-51 (2001)

Horie, H., Matsumoto, T., Takahashi, M., Nakazawa, Y., Yokohama, H., Minai, K. and Kinoshita, M.
Angiographically documented coronary steal phenomenon evoked by the intracoronary infusion of bradykinin.
Jpn. Circ. J. 65, 123-125 (2001)

Lischetzki, G., Rukwied, R., Handwerker, H. O. and Schmelz, M.
Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin.
Eur. J. Pain. 5, 49-57 (2001)

Maguire, S. M., McAuley, D., McGurk, C., Nugent, A. G., Johnston, G. D. and Nicholls, D. P.
Bradykinin infusion in chronic cardiac failure and the effects of captopril.
Eur. J. Heart Fail. 3, 671-677 (2001)

Matsumoto, T., Horie, H., Minai, K., Yokohama, H., Takashima, H., Ohira, N., Tsutui, T., Takahashi, M. and Kinoshita, M.
Coronary vasomotor responses to bradykinin and acetylcholine in patients with coronary spastic angina.
Jpn. Circ. J. 65, 1052-1056 (2001)

Minai, K., Matsumoto, T., Horie, H., Ohira, N., Takashima, H., Yokohama, H. and Kinoshita, M.
Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors.
J. Am. Coll. Cardiol. 37, 1565-1570 (2001)

Newton, D. J., Khan, F. and Belch, J. J.
Assessment of microvascular endothelial function in human skin.
Clin. Sci. (Lond) 101, 567-572 (2001)

Prasad, A., Mincemoyer, R. and Quyyumi, A. A.
Anti-ischemic effects of angiotensin- converting enzyme inhibition in hypertension.
J. Am. Coll. Cardiol. 38, 1116-1122 (2001)

Ricciardolo, F. L., Timmers, M. C., Geppetti, P., van Schadewijk, A., Brahim, J. J., Sont, J. K., de Gouw, H. W., Hiemstra, P. S., van Krieken, J. H. and Sterk, P. J.
Allergen-induced impairment of bronchoprotective nitric oxide synthesis in asthma.
J. Allergy Clin. Immunol. 108, 198-204 (2001)

Wilsdorf, T., Gainer, J. V., Murphey, L. J., Vaughan, D. E. and Brown, N. J.
Angiotensin-(1-7) does not affect vasodilator or TPA responses to bradykinin in human forearm.
Hypertension 37, 1136-1140 (2001)



Brown, N. J., Gainer, J. V., Murphey, L. J. and Vaughan, D. E.
Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway.
Circulation 102, 2190-2196 (2000)

Chalon, S., Moreno, H., Jr., Benowitz, N. L., Hoffman, B. B. and Blaschke, T. F.
Nicotine impairs endothelium-dependent dilatation in human veins in vivo.
Clin. Pharmacol. Ther. 67, 391-397 (2000)

Duchna, H. W., Guilleminault, C., Stoohs, R. A., Faul, J. L., Moreno, H., Hoffman, B. B. and Blaschke, T. F.
Vascular reactivity in obstructive sleep apnea syndrome.
Am. J. Respir. Crit. Care Med. 161, 187-191 (2000)

Kim, K. S., Kumar, S., Simmons, W. H. and Brown, N. J.
Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans.
J. Pharmacol. Exp. Ther. 292, 295-298 (2000)

Maniscalco, M., Sofia, M., Faraone, S. and Carratu, L.
The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide.
Allergy 55, 757-761 (2000)

Murphey, L. J., Gainer, J. V., Vaughan, D. E. and Brown, N. J.
Angiotensin-converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin.
Circulation 102, 829-832 (2000)

Murphey, L. J., Hachey, D. L., Oates, J. A., Morrow, J. D. and Brown, N. J.
Metabolism of bradykinin In vivo in humans: identification of BK1-5 as a stable plasma peptide metabolite.
J. Pharmacol. Exp. Ther. 294, 263-269 (2000)

Prasad, A., Husain, S., Schenke, W., Mincemoyer, R., Epstein, N. and Quyyumi, A. A.
Contribution of bradykinin receptor dysfunction to abnormal coronary vasomotion in humans.
J. Am. Coll. Cardiol. 36, 1467-1473 (2000)



Benacerraf, S., Carville, C., Adnot, S., Montagne, O., Sediame, S., Belhassen, L. and Dubois-Rande, J. L.
Improvement of bradykinin endothelium-mediated vasodilation of forearm resistance circulation by quinaprilat in patients with coronary artery disease with or without left ventricular dysfunction.
J. Cardiovasc. Pharmacol. 34, 368-373 (1999)

Berkenboom, G., Crasset, V., Unger, P., Vachiery, J. L. and LeClerc, J. L.
Absence of L-arginine effect on coronary hypersensitivity to serotonin in cardiac transplant recipients.
Am. J. Cardiol. 84, 1182-1186 (1999)

Brown, N. J., Gainer, J. V., Stein, C. M. and Vaughan, D. E.
Bradykinin stimulates tissue plasminogen activator release in human vasculature.
Hypertension 33, 1431-1435 (1999)

Chalon, S., Moreno, H., Jr., Hoffman, B. B. and Blaschke, T. F.
Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers.
Clin. Pharmacol. Ther. 65, 295-303 (1999)

Chalon, S., Tejura, B., Moreno, H., Jr., Urae, A., Blaschke, T. F. and Hoffman, B. B.
Role of nitric oxide in isoprenaline and sodium nitroprusside-induced relaxation in human hand veins.
Br. J. Clin. Pharmacol. 47, 91-98 (1999)

Dietz, N. M.
Gender and nitric oxide-mediated vasodilation in humans.
Lupus 8, 402-408 (1999)

Kato, M., Shiode, N., Teragawa, H., Hirao, H., Yamada, T., Yamagata, T., Matsuura, H. and Kajiyama, G.
The role of nitric oxide in bradykinin-induced dilation of coronary resistance vessels in patients with hypercholesterolemia.
Intern. Med. 38, 394-400 (1999)

Kharitonov, S. A., Sapienza, M. M., Chung, K. F. and Barnes, P. J.
Prostaglandins mediate bradykinin-induced reduction of exhaled nitric oxide in asthma.
Eur. Respir. J. 14, 1023-1027 (1999)

Leesar, M. A., Stoddard, M. F., Manchikalapudi, S. and Bolli, R.
Bradykinin-induced preconditioning in patients undergoing coronary angioplasty.
J. Am. Coll. Cardiol. 34, 639-650 (1999)

Prasad, A., Husain, S. and Quyyumi, A. A.
Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition: a potential role of bradykinin.
J. Am. Coll. Cardiol. 33, 796-804 (1999)

Vajo, Z., Szekacs, B., McDonald, M. H., Takahashi, B., Srivathsan, K. and Dachman, W. D.
Paradoxically enhanced bradykinin-induced venodilation in young, healthy, short-term smokers.
J. Cardiovasc. Pharmacol. 34, 316-319 (1999)



Laine, H., Yki-Jarvinen, H., Kirvela, O., Tolvanen, T., Raitakari, M., Solin, O., Haaparanta, M., Knuuti, J. and Nuutila, P.
Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity.
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Moreno, H., Jr., Chalon, S., Urae, A., Tangphao, O., Abiose, A. K., Hoffman, B. B. and Blaschke, T. F.
Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation.
Am. J. Physiol. 275, H1040-1045 (1998)



Ashworth, J. R., Warren, A. Y., Baker, P. N. and Johnson, I. R.
Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia.
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Brown, N. J., Nadeau, J. H. and Vaughan, D. E.
Selective stimulation of tissue-type plasminogen activator (t-PA) in vivo by infusion of bradykinin.
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Doull, J., Sandall, D., Smith, S., Schreiber, J., Freezer, N. J. and Holgate, S. T.
Differential inhibitory effect of regular inhaled corticosteroid on airway responsiveness to adenosine 5' monophosphate, methacholine, and bradykinin in symptomatic children with recurrent wheeze.
Pediatr. Pulmonol. 23, 404-411 (1997)

Kato, M., Shiode, N., Yamagata, T., Matsuura, H. and Kajiyama, G.
Coronary segmental responses to acetylcholine and bradykinin in patients with atherosclerotic risk factors.
Am. J. Cardiol. 80, 751-755 (1997)

Vajo, Z., McDonald, M., Takahashi, B., Zafar, H., Srivathsan, K. and Dachman, W. D.
Bradykinin-induced venodilation is not different in blacks.
Br. J. Clin. Pharmacol. 44, 285-288 (1997)



Austin, C. E., Dear, J. W., Neighbour, H., Lund, V. and Foreman, J. C.
The contribution of histamine to the action of bradykinin in the human nasal airway.
Immunopharmacology 34, 181-189 (1996)

Brown, N. J., Ryder, D., Gainer, J. V., Morrow, J. D. and Nadeau, J.
Differential effects of angiotensin converting enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin.
J. Pharmacol. Exp. Ther. 279, 703-712 (1996)

Gainer, J. V., Nadeau, J. H., Ryder, D. and Brown, N. J.
Increased sensitivity to bradykinin among African Americans.
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Marshman, G., Burton, J. L. and Archer, C. B.
Comparison of the actions of kallidin and bradykinin in the skin of normal and psoriatic subjects.
Clin. Exp. Dermatol. 21, 112-115 (1996)

Nuutila, P., Raitakari, M., Laine, H., Kirvela, O., Takala, T., Utriainen, T., Makimattila, S., Pitkanen, O. P., Ruotsalainen, U., Iida, H., Knuuti, J. and Yki-Jarvinen, H.
Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography.
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Ricciardolo, F. L., Geppetti, P., Mistretta, A., Nadel, J. A., Sapienza, M. A., Bellofiore, S. and Di Maria, G. U.
Randomised double-blind placebo-controlled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthma.
Lancet 348, 374-377 (1996)

Riccio, M. M. and Proud, D.
Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes.
J. Allergy Clin. Immunol. 97, 1252-1263 (1996)

Schaefer, S., Valente, R. A., Laslett, L. J. and Longhurst, J. C.
Cardiac reflex effects of intracoronary bradykinin in humans.
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