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Bachem AG Bachem Americas, Inc.
Hauptstrasse 144 3132 Kashiwa Street
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA
Tel +41 61 935 2323 Tel +1 888 422 2436
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Solid phase peptide synthesis

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Solid-phase peptide synthesis, the standard method for obtaining peptides. The peptide, linked by its C-terminus to a carrier, an inert, insoluble but swellable polymer, is elongated stepwise. The method can be fully automated. Fmoc- and Boc-SPPS differ in the choice of the temporary (= Boc or Fmoc) and permanent (side-chain) protecting groups. The type of Nα-blocking group determines the options for side-chain protection and the conditions of final cleavage (removal of the permanent protective groups and splitting from the carrier). Fmoc-SPPS is considered the milder method.

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