Europe/India/Near East USA Asia
Bachem AG Bachem Americas, Inc. Bachem Japan K.K.
Hauptstrasse 144 3132 Kashiwa Street AREA Shinagawa, 13F
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA Tokyo 108-0075 - Japan
Tel +41 58 595 2021 Tel +1 888 422 2436 Tel +81 70 7460 2583
Fax +41 58 595 2040 Tel +1 888 4BACHEM Email sales.jp@bachem.com
Email sales.ch@bachem.com Fax +1 310 539 9428  
  E-mail sales.us@bachem.com  

GLOSSARY & ABBREVIATIONS

Dmb

2,4-Dimethoxybenzyl

back to overview

2,4-Dimethoxybenzyl, acid-labile carboxamide protecting group used for the reversible backbone modification of peptides. Incorporation of Fmoc-Dmb amino acids  or dipeptides (Fmoc-Xaa-DmbYaa-OH) during Fmoc-SPPS prevents aggregation and thus facilitates the elongation of the peptide. Facilitation of cyclization reactions and prevention of aspartimide formation are further applications of Dmb backbone protection.
Unlike Hmb amino acids/dipeptides, Dmb derivatives cannot form benzo-oxazepinones during activation.

back to overview