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S.S.Chauhan and H.J.Wilk
Efficient stereocontrolled synthesis of (S)-Fmoc-β-nitroalanine via oxidation of oxime
THL 51, 3340-3343 (2010)
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T.Vorherr
Recent developments to encourage the synthesis of complex peptides
PharmaChem 9 (3/4), 19-23 (2010) |
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T.Vorherr
Critical parameters for solid-phase manufacturing of therapeutic peptides
Chim. Oggi 28, 22-25 (2010) |
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S.Rangaraju, K.K.Khoo, Z.-P.Feng, G.Crossley, D.Nugent, I.Khaytin, V.Chi, C.Pham, P.Calabresi, M.W.Pennington, R.S.Norton, and K.G.Chandy
Potassium channel modulation by a toxin domain in matrix metalloprotease 23
J. Biol. Chem. 285, 9124-9136 (2010) |
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S.Chauhan
Enantioselective synthesis of (L)-Fmoc-α-Me-Lys(Boc)-OH via diastereoselective alkylation of oxazinone as a chiral auxiliary
THL 50, 6913-6915 (2009) |
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M.W.Pennington, C.Beeton, C.A.Galea, B.J.Smith, V.Chi, K.P.Monaghan, A.Garcia, S.Rangaraju, A.Giuffrida, D.Plank, G.Crossley, D.Nugent, I.Khaytin, Y.LeFievre, I.Peshenko, C.Dixon, S.Chauhan, A.Orzel, T.Inoue, X.Hu, R.V.Moore, R.S.Norton, and K.G.Chandy
Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes
Mol. Pharmacol. 75, 762–773 (2009) |
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T.Vorherr
Peptides as drugs - Molecular evolvement in recent years
PharmaChem 7 (9), 13-16 (2008) |
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M.Vaara, J.Fox, G.Loidl, O.Siikanen, J.Apajalahti, F.Hansen, N.Frimodt-Møller, J.Nagai, M.Takano and T.Vaara
Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents
Antimicrob. Agents Chemother. 52, 3229-3236 (2008) |
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M.P.Matheu, C.Beeton, A.Garcia, V.Chi, S.Rangaraju, O.Safrina, K.Monaghan, M.I.Uemura, D.Li, S.Pal, L.M.de la Maza, E.Monuki, A.Flügel, M.W.Pennington, I.Parker, K.G.Chandy and M.D.Cahalan
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block
Immunity 29, 1-13 (2008) |
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M.Obkircher, C.Stähelin and F.Dick
Formation of Fmoc-β-alanine during Fmoc-protections with Fmoc-OSu
J. Pept. Sci. 14, 763-766 (2008) |
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C.Beeton, B.J.Smith, J.K.Sabo, G.Crossley, D.Nugent, I.Khaytin, V.Chi, K.G.Chandy, M.W.Pennington and R.S.Norton
The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation
J. Biol. Chem. 283, 988-997 (2008) |
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H.Wulff and M.Pennington
Targeting effector memory T-cells with Kv1.3 blockers
Curr. Opin. Drug Discov. Devel. 10, 438-445 (2007) |
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J.A.Durr, M.Blankenship, S.S.Chauhan and M.W.Pennington
Targeted tyrosine iodination in a multi-tyrosine vasopressin analog
J. Pept. Sci. 13, 756-761 (2007) |
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L.Hu, M.Pennington, Q.Jiang, K.A.Whartenby and P.A.Calabresi
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes
J. Immunol. 179, 4563-4570 (2007) |
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F.Dick, M.Mergler, G.Loidl, R.Schönleber and T.Vorherr
Purification of sparingly soluble peptides by temporary solubilization
Proceedings of the 29th European Peptide Symposium, Gdansk (2006). Kenes International, Switzerland (2007) |
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S.Chauhan, A.Varshney, B.Verma and M.W.Pennington
Efficient synthesis of protected L-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis
THL. 48, 4051-4054 (2007) |
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T.Vorherr
Purification: The bottleneck in peptide production
Spec. Chem. 27, 40-42 (2007) |
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T.Vorherr
Approaches for the purification of sparingly soluble peptides
Chim. Oggi 25, 22-24 (2007) |
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C.Beeton, H.Wulff, N.E.Standifer, P.Azam, K.M.Mullen, M.W.Pennington, A.Kolski-Andreaco, E.Wei, A.Grino, D.R.Counts, P.H.Wang, C.J.LeeHealey, B.S.Andrews, A.Sankaranarayanan, D.Homerick, W.W.Roeck, J.Tehranzadeh, K.L.Stanhope, P.Zimin, P.J.Havel, S.Griffey, H.-G.Knaus, G.T.Nepom, G.A.Gutman, P.A.Calabresi, and K.G.Chandy
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
Proc. Natl. Acad. Sci. USA 103, 17414–17419 (2006) |
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K.M.Mullen, M.Rozycka, H.Rus, L.Hu, C.Cudrici, E.Zafranskaia, M.W.Pennington, D.C.Johns, S.I.V.Judge and P.A.Calabresi
Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system
Ann. Neurol. 60, 118–127 (2006) |
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T.Vorherr
Peptides: Impact of new technologies on chemical production
PharmaChem 5 (7/8), 14-17 (2006) |
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T.Kawakami, M.Sumida, K.Nakamura, T.Vorherr and S.Aimoto
Peptide thioester preparation based on an N-S acyl shift reaction mediated by a thiol ligation auxiliary
THL 46, 8805-8807 (2005) |
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M.Mergler and F.Dick
The aspartimide problem in Fmoc-based SPPS. Part III
J. Peptide Sci.11, 650-657 (2005) |
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T.Vorherr, F.Dick and B.Sax
Bachem, a Swiss Speciality cGMP-Manufacturer:
History and Future Prospects
Chimia 59, 25-27 (2005) |
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S.Singh, G.Crossley, S.Ghosal, Y.Lefievre and M.Pennington
A short practical synthesis of 2'-deoxymugineic acid
THL 46, 1419-1421 (2005) |
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C.Beeton, M.W.Pennington, H.Wulff, S.Singh, D.Nugent, G.Crossley, I.Khaytin, P.A.Calabresi, C.Chen, G.A.Gutman and K.G.Chandy
Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
Mol. Pharmacol. 67, 1369-1981 (2005) |
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X.Lauth, J.J.Babon, J.A.Stannard, S.Singh, V.Nizet, J.M.Carlberg, V.E.Ostland, M.W.Pennington, R.S.Norton and M.E.Westerman
Bass Hepcidin Synthesis, Solution Structure, Antimicrobial Activities and Synergism, and in Vivo Hepatic Response to Bacterial Infections
J. Biol. Chem. 280, 9272-9282 (2005) |
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R.S.Norton, M.W.Pennington and H.Wulff
Potassium Channel Blockade by the Sea Anemone Toxin ShK for the Treatment of Multiple Sclerosis and Other Autoimmune Diseases
Curr. Med. Chem. 11, 3141-3152 (2004) |
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S.Singh
Asymmetric synthesis of (R)- and (S)-a-methylcysteine
Recent Res. Devel. Organic Chem. 8, 323-339 (2004) |
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H.Wulff, H.G.Knaus, M.Pennington, and K.G.Chandy
K+ Channel Expression during B Cell Differentiation:
Implications for Immunomodulation and Autoimmunity
J. Immunol. 173, 776-786 (2004) |
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S.Singh, S.J.Rao and M.W.Pennington
Efficient Asymmetric Synthesis of (S)- and (R)-N-Fmoc-S-Trityl-a-methylcysteine Using Camphorsultam as a Chiral Auxiliary
J. Org. Chem. 69, 4551-4554 (2004) |
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K.G.Chandy, H.Wulff, C.Beeton, M.Pennington, G.A.Gutman and M.D.Cahalan
K+ channels as targets for specific immunomodulation
TIPS 25, 280-289 (2004) |
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S.F.Brady, S.Singh, M.C.Crouthamel, M.K.Holloway, C.A.Coburn, V.M.Garsky, M.Bogusky, M.W.Pennington, J.P.Vacca, D.Hazuda and M.T.Lai
Rational design and synthesis of selective BACE-1 inhibitors
Bioorg. Med. Chem. Lett. 14, 601-604 (2004) |
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S.Singh, I.Khaytin, S.Botsko, G.Crossley, D.K.Plank, Y.Lefievre, F.Giuffrida and M.W.Pennington
Addition of o-aminobenzoic acid during Fmoc solid phase synthesis of a fluorogenic substrate containing 3-nitrotyrosine
Lett. Peptide Sci. 9, 221-225 (2002) |
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T.Vorherr
A very bright future for cGMP-manufacturing of peptides
Chim. Oggi 21, 14-15 (2003) |
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M. Mergler, F. Dick, B. Sax, C. Stähelin and T. Vorherr
The Aspartimide Problem in Fmoc-based SPPS. Part II
J. Peptide Sci. 9, 518-526 (2003) |
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A. F. Kisselev, M. Garcia-Calvo, H. S. Overkleeft, E. Peterson, M. W. Pennington, H. L. Ploegh, N. A. Thornberry and A. L. Goldberg
The caspase-like sites of proteasomes: substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
J. Biol. Chem. 278, 35869-35877 (2003) |
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H. Wulff, P. A. Calabresi, R. Allie, S. Yun, M. Pennington, C. Beeton, and K. G. Chandy
The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS
J. Clin. Invest. 111, 1703-1713 (2003) |
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S. Singh and M. Pennington
An efficient asymmetric synthesis of Fmoc-L-cyclopentylglycine via diastereoselective alkylation of glycine enolate equivalent
THL 44, 2683-85 (2003) |
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