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New Monograph: Ghrelin, Leptin and Obestatin

13. Jun 2012

The new product monograph 'Ghrelin, Leptin and Obestatin' gives you an overview of BachemĀ“s offer of obesity-related products.
This revised edition has been enriched with clickable product deeplinks leading directly to the respective products in our Online Shop.

 
Ghrelin is an endogenous peptide discovered by Kojima et al. in 1999 during the search of an unknown endogenous ligand of a receptor of known structure and function. It is a 28 amino acid peptide with an essential n-octanoyl modification on the hydroxy group of Ser3 and displays strong growth hormone-releasing activity mediated by the growth hormone secretagogue receptor 1a (GHS-R1a). Ghrelin also participates in the regulation of energy homeostasis, increases food intake, and decreases energy expenditure by lower-ing the catabolism of fat.
Several years after the isolation of ghrelin a second peptide derived from preproghrelin was isolated from rat stomach. This 23 amino acid peptide named obestatin was initially considered to oppose the orexigenic (appetite-stimulating) effects of ghrelin. It was also reported to be the cognate ligand for the G-protein coupled receptor GPR39. Later studies, however, cast doubt on the initial findings as subsequent studies failed to confirm the anorexigenic effects of obestatin.
Leptin, a satiety hormone produced by white adipose tissue, was discovered in 1994 and represents another appetite regulator. Leptin and ghrelin are supposed to share hypothalamic pathways regulating food intake and energy homeostasis.

 

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