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GLOSSARY & ABBREVIATIONS

Hyp

trans-4-Hydroxy-L-prolyl ((2S,4R)-4-Hydroxypyrrolidine-2-carbonyl)

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L-trans-Hydroxyproline is generated post-translationally by oxidation of proline. Hyp is a major constituent of collagen and mussel proteins.
O-protection of Hyp during Fmoc-SPPS is recommandable but not absolutely mandatory. The secondary hydroxyl function is somewhat more accessible than the Thr hydroxyl moiety.

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