Europe/Asia USA
Bachem AG Bachem Americas, Inc.
Hauptstrasse 144 3132 Kashiwa Street
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA
Tel +41 61 935 2323 Tel +1 888 422 2436
Fax +41 61 935 2325 +1 888 4BACHEM
E-mail sales.ch@bachem.com +1 310 539 4171
  Fax +1 310 539 9428
  E-mail sales.us@bachem.com

GLOSSARY & ABBREVIATIONS

Bzl

Benzyl

back to overview

Benzyl (Bzl) an alkyl residue and a side-chain protecting group employed in Boc/Bzl-based SPPS and solution synthesis. Bzl is commonly used for blocking alcohols (Ser, Thr, Hyp), it is cleaved by strong acids or catalytic hydrogenolysis (e.g. hydrogen/Pd). Deblocking of N-Bzl and S-Bzl requires much harsher conditions. The acid lability of benzyl ethers, esters (see OBzl), thiols, and amines can be modulated by introducing  substituents at the ╬▒-carbon or the aromat, e.g. halogens for improving or ╬▒-substituents for decreasing the acid stability.

back to overview