Europe/Asia USA
Bachem AG Bachem Americas, Inc.
Hauptstrasse 144 3132 Kashiwa Street
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA
Tel +41 61 935 2323 Tel +1 888 422 2436
Fax +41 61 935 2325 +1 888 4BACHEM
E-mail sales.ch@bachem.com +1 310 539 4171
  Fax +1 310 539 9428
  E-mail sales.us@bachem.com

NP MARCH 2016

BACHEM  PIONEERING  PARTNER  FOR PEPTIDES
  NEW PRODUCTS ALERT
March 2016 EDITION
 

Now available @ shop.bachem.com

Bachem is continuously expanding and updating its extensive range of products for your research purposes. 

We are pleased to present our latest products:

Alzheimer's Disease Related Products
 
H-8146 Amyloid β-Protein (1-42) TFA Salt
H-7666 FITC-εAhx-Amyloid β-Protein (1-42)
H-7686 (Des-Glu²²)-Amyloid β-Protein (1-42)
The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.
H-7664 Amyloid β-Protein (1-40) amide
H-7662 (Arg¹³)-Amyloid β-Protein (1-40)
H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
H-7728 Amyloid β-Protein (40-1)
Inactive control
H-7656 Amyloid β-Protein (1-24)
H-7672 Amyloid β-Protein (3-40)
H-7668 Amyloid β-Protein (11-42)
H-7658
 
Acetyl-(N-Me-Leu¹⁷,N-Me-Phe¹⁹)-
Amyloid β-Protein (16-20) amide
Membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis.
H-7674
 
Amyloid Precursor Frameshift
Mutant C-Terminal Peptide
The sequence RGRTSSKELA corresponds to human APP frameshift mutant (339-348). RGRTSSKELA is used for generating antibodies.
H-7762 Galanin (human)
Galanin has been shown to inhibit acetylcholine release, glutamate release and carbachol-stimulated phosphatidylinositol hydrolysis in the hippocampus. The peptide hormone is also linked to behavioral and cognitive deficits in Alzheimer's disease.
H-7604 TRAF6 Peptide
The cell-permeable peptide inhibits the interaction of TRAF6, an E3 ubiquitin ligase, with p62 (sequestosome 1). P62 has been shown to be a polyubiquitin shuttling factor which binds to K63-polyubiquitinated proteins. TRAF6-p62 interaction modulators may be used to treat neuropathologies such as Alzheimer's disease or Huntington's disease. For a control peptide see H-7606.
H-7606 TRAF6 Control Peptide
Inactive control for the TRAF6-p62 interaction modulator H-7604, the sequence differs in three positions.
C-4275 1,3-Bis-(Z-Leu-Leu)-diaminoacetone
(Z-LL)₂ Ketone, cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC₅₀ ca. 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasome.

Further Peptides
 
Uroguanylin
H-8142 Uroguanylin Topoisomer B (human)

Building Blocks
 
Cysteine-containing Pseudoproline Dipeptides
Ser and Thr pseudoproline dipeptides play a crucial role in Fmoc-SPPS. The corresponding Cys derivatives broaden the scope of pseudoproline application, especially as cysteine can be desulfurated yielding alanine.
2,4-dimethoxyphenyl(Dmp)-thiaproline is compatible with standard Fmoc/tBu protocols and can be cleaved with 80% TFA in DCM.
B-4365 Fmoc-Ala-Cys(Psi(Me,Me)pro)-OH
B-4395 Fmoc-Gly-Cys(Psi(Dmp,H)pro)-OH
B-4400 Fmoc-Leu-Cys(Psi(Dmp,H)pro)-OH
B-4405 Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)pro)-OH
B-4410
 
Fmoc-Val-Cys(Psi(Dmp,H)pro)-OH
 
F-4290 H-β-Cyclohexyl-Ala-OMe · HCl
A-4785 Boc-Cys(StBu)-OH
StBu is cleaved by mercaptans, phosphines and other reducing agents. As it is stable towards TFA it is suitable for Boc-SPPS.
 
B-4445 Fmoc-Cys(NPys)-OH
Npys allows site-directed disulfide bond formation, as it is cleaved by thiols.
 
B-4465 Fmoc-His-OMe
B-4505 Fmoc-Lys(palmitoyl-Glu-OtBu)-OH

E-BROCHURES

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Contact Us

Europe, Africa, Middle East and Asia Pacific:
Bachem AG
Tel: +41 58 595 2020

sales.ch@bachem.com

Americas:
Bachem Americas, Inc.
Toll Free (USA and Canada): +1 888 422 2436 or Tel: +1 310 539 4171

sales.us@bachem.com

Visit our website at www.bachem.com
or shop online at shop.bachem.com.
 

All information is compiled to the best of our knowledge. We cannot be made liable for any possible errors or misprints.
Some products may be restricted in certain countries.

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