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This section contains the archived scientific articles on peptide synthesis and research with contributions from our researchers.

Our most recent published scientific articles in the field of peptide research and peptide synthesis can be found in the section
Bachem literature.

A very bright future for cGMP-manufacturing of peptides
Chim. Oggi 21, 14-15 (2003)

M.Mergler, F.Dick, B.Sax, C.Stähelin and T.Vorherr
The aspartimide problem in Fmoc-based SPPS. Part II
J. Pept. Sci. 9, 518-526 (2003)

A.F.Kisselev, M.Garcia-Calvo, H.S.Overkleeft, E.Peterson, M.W.Pennington, H.L.Ploegh, N.A.Thornberry and A.L.Goldberg
The caspase-like sites of proteasomes: substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
J. Biol. Chem. 278, 35869-35877 (2003)

H.Wulff, P.A.Calabresi, R.Allie, S.Yun, M.Pennington, C.Beeton and K.G.Chandy
The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS
J. Clin. Invest. 111, 1703-1713 (2003)

S.Singh and M.Pennington
An efficient asymmetric synthesis of Fmoc-L-cyclopentylglycine via diastereoselective alkylation of glycine enolate equivalent
Tetrahedron Lett. 44, 2683-2685 (2003)

M.Mergler, F.Dick, B.Sax, P.Weiler and T.Vorherr
The aspartimide problem in Fmoc-based SPPS. Part I
J. Pept. Sci. 9, 36-46 (2003)

M.D.Lanigan, H.Wulff, S.Singh, S.Botsko, G.Crossley, G.A.Gutman, M.D.Cahalan, M.Pennington and K.G.Chandy
A novel fluorescent toxin to detect and investigate Kv1.3 channel upregulation in chronically activated T lymphocytes
J. Biol. Chem. 278, 9928-9937 (2003)

S.Singh, I.Khaytin, S.Botsko, G.Crossley, D.K.Plank, Y.Lefievre, F.Giuffrida and M.W.Pennington
Addition of o-aminobenzoic acid during Fmoc solid phase synthesis of a fluorogenic substrate containing 3-nitrotyrosine
Lett. Pept. Sci. 9, 221-225 (2002)

M.D.Lanigan, K.Kalman, Y.Lefievre, M.W.Pennington, K.G.Chandy and
R. S.Norton
Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3
Biochemistry 41, 11963-11971 (2002)

J.Vizzavona, F.Dick and T.Vorherr
Synthesis and application of an auxiliary group for chemical ligation at the X-Gly site
Bioorg. Med. Chem. Lett. 12, 1963-1965 (2002)

C.Beeton, H.Wulff, J.Barbaria, O.Clot-Faybesse, M. Pennington, D.Bernard, M. D.Cahalan, K.G.Chandy and E.Béraud
Selective blockade of T lymphocyte K channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
Proc. Natl. Acad. Sci. USA 98, 13942-13947 (2001)

M.D.Lanigan, M.W.Pennington, Y.Lefievre, H.Rauer and R.S.Norton
Designed peptide analogues of the potassium channel blocker ShK toxin
Biochemistry 40, 15528-15537 (2001)

M.Mergler, F.Dick, B.Sax, J.Schwindling and T.Vorherr
Synthesis and application of Fmoc-His(3-Bum)-OH
J. Pept. Sci. 7, 502-510 (2001)

K.G.Chandy, M.Cahalan, M.Pennington, R.S.Norton, H.Wulff and G.A.Gutman
Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants
Toxicon 39, 1269-1276 (2001)

M.D.Lanigan, J.E.Tudor, M.W.Pennington and R.S.Norton
A helical capping motif in ShK toxin and its role in helix stabilization
Biopolymers 58, 422-436 (2001)

M.Mergler, F.Dick, J.Gosteli and R.Nyfeler.
Protected peptide p-nitroanilides by solid-phase synthesis
Lett. Pept. Sci. 7, 1-7 (2000)

Th.Mindt, U.Michel and F.Dick
Synthesis and evaluation of enantiomeric purity of protected alpha-amino and peptide aldehydes
Helv. Chim. Acta 82, 1960-1968 (1999)

M.W.Pennington, M.Lanagin, K.Kalman, V.M.Mahnir, H.Rauer, C.T.McVaugh, D.Behm, D.Donaldson, K.G.Chandy, W.R.Kem and R.S.Norton
The role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin
Biochemistry 38, 14549-14558 (1999)

H.Rauer, M.W.Pennington, M.Cahalan and K.G.Chandy
Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin
J. Biol. Chem. 274, 21885-21892 (1999)

W.R.Kem, M.W.Pennington and R.S.Norton
Sea anemone toxins as templates for the design of immunosuppressant drugs
Perspect. Drug Discov. Design. 15/16, 111-129 (1999)

SASRINTM. A review of its manifold applications including many useful procedures
Brochure published by BACHEM (1st ed. 1995, 2nd revised and enlarged ed. 1999)

M.Mergler and R.Nyfeler
Polymeric diphenyldiazomethane. A useful resin for SPPS and solid-phase organic chemistry
Proceedings of the 5th Int. Symp. Innovation and Perspectives in SPPS, London (1997).
Mayflower Scientific Ltd., Birmingham (1999)

M.Mergler, J.Gosteli, P.Grogg, R.Nyfeler and R.Tanner.
SASRINTM Resin, a versatile tool in peptide synthesis and solid phase organic chemistry
Chimia 53, 29-34 (1999)

M.Mergler, F.Dick, J.Gosteli and R.Nyfeler.
Solid phase synthesis of fully protected peptide alcohols
Tetrahedron Lett. 40, 4663-4664 (1999)

T.R.Pray, A.M.Nomura, M.W.Pennington and C.S.Craik.
Auto-inactivation by cleavage whitin the dimer interface of Kaposi's sarcoma-associated herpesvirus protease
J. Mol. Biol. 289, (2), 197-203 (1999)

F.Dick, E.Kulow, R.Nyfeler, B.Rohwedder and T.Vorherr.
Racemization upon activation and coupling to a fluorophore containing building block
p.254 in: Peptides 1998
, Proceedings of the 25th European Peptide Symposium,
August 30 - September 4, 1998, Budapest, Hungary, edited by S. Bajusz and F. Hudecz (1999)