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Bachem AG Bachem Americas, Inc.
Hauptstrasse 144 3132 Kashiwa Street
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA
Tel +41 61 935 2323 Tel +1 888 422 2436
Fax +41 61 935 2325 +1 888 4BACHEM
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PRODUCT MONOGRAPHS

Bachem offers for free a series of brochures on selected groups of products in peptide research and detailed manuals on peptide synthesis.

Product Monographs

Amyloid Peptides
Products for Alzheimer's Research
 
Extracellular amyloid-β peptide deposition into cerebellar plaques and formation of intracellular neurofi brillary fi bers accompanied by the loss of neurons are characteristic histopathological lesions found in the brains of Alzheimer‘s disease patients. Individuals suffering from this disease show a gradual loss of cognitive functions and disturbances in behavior. Apart from some rare familial forms of the disease, the onset of Alzheimer‘s disease is usually above 60 years. Since the risk to develop the disease increases with age, Alzheimer‘s disease has become a major health and social problem in the developed countries with an increasing proportion of older people. In this brochure we present amyloid peptides and related products for Alzheimer‘s disease research.
(pdf, 2 MB) Bachem
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Amyloid Peptides JP
Extracellular amyloid-β peptide deposition into cerebellar plaques and formation of intracellular neurofi brillary fi bers accompanied by the loss of neurons are characteristic histopathological lesions found in the brains of Alzheimer‘s disease patients. Individuals suffering from this disease show a gradual loss of cognitive functions and disturbances in behavior. Apart from some rare familial forms of the disease, the onset of Alzheimer‘s disease is usually above 60 years. Since the risk to develop the disease increases with age, Alzheimer‘s disease has become a major health and social problem in the developed countries with an increasing proportion of older people. In this brochure we present amyloid peptides and related products for Alzheimer‘s disease research.
(pdf, 2 MB)
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Antimicrobial Peptides
Ribosomally synthesized antimicrobial peptides (AMPs) constitute a structurally diverse group of molecules found virtually in all organisms. Most antimicrobial peptides contain less than 100 amino acid residues, have a net positive charge, and are membrane active. They are major players in the innate immune defense but can also have roles in processes as chemokine induction, chemotaxis, infl ammation, and wound healing. In addition to their antimicrobial effects, many of them show antiviral and antineoplastic activities.
(pdf, 1 MB) Bachem
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Antimicrobial Peptides (Chinese Version)
Ribosomally synthesized antimicrobial peptides (AMPs) constitute a structurally diverse group of molecules found virtually in all organisms. Most antimicrobial peptides contain less than 100 amino acid residues, have a net positive charge, and are membrane active. They are major players in the innate immune defense but can also have roles in processes as chemokine induction, chemotaxis, infl ammation, and wound healing. In addition to their antimicrobial effects, many of them show antiviral and antineoplastic activities.
(pdf, 1 MB)
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CGRP Peptides
Calcitonin Gene-Related Peptides
 
Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide which belongs to a family of related peptides including calcitonin, amylin, and adrenomedullin. It exists in two isoforms α-CGRP (or CGRP I) and β-CGRP (or CGRP II) which are very similar in their biological activities but are encoded by different genes. CGRP peptides are mainly localized in sensory and central neurons and have been implicated in a variety of physiological processes such as cardiovascular homeostasis, calcium metabolism, and control of fetoplacental vascular tone. Receptors for this family of peptides belong to the seven transmembrane G-protein-coupled receptors linked to the activation of adenylate cyclase. Their interaction with receptor activity modifying proteins (RAMPs) is essential for membrane trafficking and for conferring ligand specificity. In this brochure we present a selection of its products for CGRP research.
(pdf, 1 MB) Bachem
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Caspase
Today the field of apoptosis research is one of the most investigated areas in modern biology. Its significance is due to the observation of the involvement of apoptosis in a growing number of several common human diseases including autoimmune disorders, neurodegenerative diseases, cancer, and AIDS. Caspases are key players in apoptosis and their activation is generally considered as the “point of no return” in apoptotic pathways. Here we present an overview of our caspase substrates and inhibitors for your apoptosis research.
(pdf, 2 MB) Bachem
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Cell permeable Peptides
Cell-penetrating peptides (CPPs) constitute a promising tool for the cellular import of drug cargos. They have been successfully applied for in vitro and in vivo delivery of a variety of therapeutic molecules including plasmids, DNA, oligonucleotides, siRNA, PNA, proteins, peptides, low molecular weight drugs, liposomes, and nanoparticles.
(pdf, 517 KB)
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Click Chemistry
Bachem highlights the importance of “click reactions” in peptide chemistry as a simple and versatile concept for peptide synthesis and chemoselective modification. The broad spectrum of applications of the reaction includes ligation, cyclization, bio-conjugation, and radiolabeling of peptides.
(pdf, 431 KB)
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Coupling Reagents
The coupling reaction i.e. the formation of an amide bond between amino acids and/or peptides is the crucial step in peptide synthesis. The reaction consists of two consecutive steps: 1. Activation of the carboxy moiety 2. Acylation of the amino group During the first step the protected amino acid (or peptide) reacts with a so-called coupling reagent yielding a reactive intermediate. The chemistry behind and the most important coupling reagents will be presented in this brochure.
(pdf, 4 MB) Bachem
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Cysteine Derivatives
Cysteine and its Derivatives in Peptide Synthesis
 
Cystine disulfide bridges help to stabilize the biologically active conformation of peptides and proteins. They are generated by incorporation of cysteine residues followed by oxidation of the thiol functions yielding disulfides („folding“). For the chemical synthesis of peptides, a range of protecting groups has been developed for blocking these sensitive moieties which may be removed either directly before or during oxidative folding. When synthesizing peptides containing two or more disulfide bonds, S-protection may have to be varied to allow consecutive bridge formation for obtaining an unambiguous structure.
(pdf, 1,019 KB) Bachem
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