Internal research projects at Bachem are primarily targeted to result in long-term commercial benefit. The continuous investment in development and implementation of new chemistries and technologies is regarded as crucial for future success. Especially, since stringent requirements from authorities and the demand for more complex structures from clients require major efforts to remain competitive. In particular, the increasing interest in longer and significantly more complex peptides up to synthetic proteins represents a challenge for all peptide manufacturers. Unlike biotechnological production, the synthetic access to these macromolecules allows for substantial fine-tuning of these structures. As a consequence, products with tailored properties can be developed, offering opportunities to achieve patent protection for the optimized structures.
This is in line with the requirements of the biotech- and pharmaceutical industries for more selective and potent medicines. In addition, ongoing research in proteomics continues to generate an incredible amount of knowledge regarding proteins and peptides derived thereof.
The enhanced interest in long peptides and even synthetic proteins is a logical consequence of this development. In particular, the progress in mass spectrometric techniques has facilitated the discovery of more complex peptides, and as considerable progress in synthesis and ligation technologies has been realized, these molecules are well within the scope of current synthetic methodologies. Bachem’s research projects originate from the idea to continuously evaluate new chemistries and technologies to improve on existing processes in a dynamic fashion.
Collaborations with external research institutions like the University of Basel are thought to complement these activities. At the University of Basel, Bachem sponsors the Bachem professorship for peptide chemistry since 1999, both to support research in peptide chemistry, and to encourage young talent in this area of organic chemistry.