Gonadorelin Acetate

H-4005-GMP, 4008614

Bachem Regulatory Documentation

CEP, DMF

Synonyms

GnRH; Gonadotropin-Releasing Hormone; LHRH; Luliberin;
Luteinizing Hormone-Releasing Factor

Sequence

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt

Fields of Application

Ovarian follicular cysts (veterinary medicine)
Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)

Active Substance

Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Molecular Information

Molecular Formula

C55H75N17O13

Relative Molecular Mass

1182.31 g/mol

CAS-Number

33515-09-2 (net), 34973-08-5 (acetate)

Long-term Storage

-20 ± 5°C