Leuprolide Acetate

Leuprolide Acetate

H-4060-GMP, 4008634

Bachem Regulatory Documentation

CEP, DMF

Synonyms

Leuprorelin; (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH

Sequence

Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate salt

Fields of Application

Advanced hormone-dependent prostate cancer
Advanced hormone-dependent breast cancer
Endometriosis
Uterine myoma
Central precocious puberty

Active Substance

Leuprolide Acetate is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of leuprolide results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. Studies with female Alzheimer patients indicate that application of leuprolide acetate in combination with an acetylcholinesterase inhibitor stabilizes the cognitive functions in mild-to-moderate cases.

Molecular Information

Molecular Formula

C59H84N16O12

Relative Molecular Mass

1209.5 (net)

CAS-Number

53714-56-0 (net), 74381-53-6 (acetate)

Long-term Storage

-20 ± 5°C