Leuprolide Acetate
H-4060-GMP, 4008634
Bachem Regulatory Documentation
CEP, DMF
Synonyms
Leuprorelin; (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
Sequence
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate salt
Fields of Application
Advanced hormone-dependent prostate cancer
Advanced hormone-dependent breast cancer
Endometriosis
Uterine myoma
Central precocious puberty
Advanced hormone-dependent breast cancer
Endometriosis
Uterine myoma
Central precocious puberty
Active Substance
Leuprolide Acetate is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of leuprolide results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. Studies with female Alzheimer patients indicate that application of leuprolide acetate in combination with an acetylcholinesterase inhibitor stabilizes the cognitive functions in mild-to-moderate cases.
Molecular Information
Molecular Formula
C59H84N16O12
Relative Molecular Mass
1209.5 (net)
CAS-Number
53714-56-0 (net), 74381-53-6 (acetate)
Long-term Storage
-20 ± 5°C