Analytical Capabilities
GMP compliant analytical capabilities
Everything analytical you need to rely on us as a GMP manufacturer – from API development to commercial supply, backed by broad analytical knowhow, state of the art methods, and full lifecycle support.
Comprehensive GMP compliant analytical services
- Ultra / High Performance Liquid Chromatography (UHPLC / HPLC) with UV, Fluorescence, CAD, RI, MALS detection
- Two-Dimensional Ultra High Performance Liquid Chromatography (2D-UHPLC)
- Gas Chromatography (GC)
- Ion Chromatography (IC)
- Thin Layer Chromatography (TLC)
- Multicolumn countercurrent solvent gradient purification (MCSGP)
Advanced mass spectrometry methods delivering precise sequencing and impurity profiling for peptides and oligonucleotides.
- Ultra High Resolution Mass Spectrometry (ESI-Orbitrap)
- High Resolution Mass Spectrometry (ESI-Q-ToF)
- Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-ToF/ToF)
- Peptide and Oligonucleotide Sequencing (ESI- & MALDI-MS/MS)
- Multiple MS/MS Methods, including:
- Collision Induced Dissociation (CID)
- Electron Transfer Dissociation (ETD)
- Electron Transfer Collision Induced Dissociation (EtciD)
- Electron Transfer Higher-Energy Collision Dissociation (EThcD)
- Higher-Energy Collisional Dissociation (HCD)
- Ultraviolet Photo Dissociation (UVPD)
- Ultra / High Performance Liquid Chromatography coupled with Mass Spectrometry (UHPLC-MS/MS / HPLC-MS/MS)
- Two-Dimensional Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry (2D-UHPLC-MS/MS)
- Gas Chromatography coupled with Mass Spectrometry (GC-MS/MS Triple Quadrupole)
- Thin Layer Chromatography (TLC) coupled with Mass Spectrometry (TLC-MS/MS)
Spectroscopic methods enabling precise structural analysis and characterization to support GMP‑compliant development.
- Infrared Spectroscopy (IR)
- Ultraviolet / Visible Spectroscopy (UV/VIS)
- Raman Spectrometry
- Fluorescence Spectroscopy
- Circular Dichroism Spectroscopy (CD)
- Nuclear Magnetic Resonance Spectroscopy (1H, 13C, 31P & 19F – NMR)
- Oligonucleotide Melting Temperature (UV melting curve)
Additional analytical methods supporting GMP development with precise titration, data integrity tools, and complementary quality‑control functionalities.
- Amino Acid Analysis (AAA)
- Automated Imaging for Particle Characterization
- Dynamic Light Scattering (DLS)
- Elemental Analysis (CHN)
- Enantiomer Content
- Endotoxins (LAL test)
- Gel Electrophoresis (Native & SDS-Page)
- Heavy Metals (ICP-MS)
- Micro Flow Imaging (MFI)
- Polarimetry
- Refractometry
- Residue on Ignition
- Sulfated Ash
- Titration (redox, potentiometric, Karl-Fischer vol./coul.)
- Total Organic Carbon (TOC)
- Total Viable Aerobic Counts (TVC)
- Turbidimetry
Data you can trust
- Fully validated LIMS and Chromatography Data Systems (CDS)
- Compliance with Computer System Validation (CSV)
- Built for regulatory inspections & audit readiness
- No manual data transfer
Why choose Bachem
End-to-end analytical support
From early development to market approval with tailored GMP‑compliant analytics.
Regulatory confidence
Methods and documentation aligned with ICH and global regulatory expectations.
Data integrity, digitally assured
LIMS, CDS, and validated digital systems meeting the highest CSV standards.
Analytical experience
Decades of industry experience setting analytical standards in peptides and oligonucleotides.
Rely on more than 50 years of experience in high-quality TIDES manufacturing
Connect with our team to discuss how our comprehensive analytical capabilities can support your molecule from early development to commercial launch.
