Buserelin
H-4224-GMP, 4038785
Bachem Regulatory Documentation
DMF
Synonyms
(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH
Sequence
Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt
acetate salt
Fields of Application
Use in reproduction medicine
Advanced hormone-dependent prostate cancer
Endometriosis
Central precocious puberty
Uterine myoma
Active Substance
Buserelin is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of buserelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Molecular Information
Molecular Formula
C60H86N16O13
Relative Molecular Mass
1239.44 g/mol
CAS-Number
57982-77-1 (net), 68630-75-1 (acetate)
Long-term Storage
-20 ± 5 °C
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