GONADORELIN ACETATE

Gonadorelin Acetate

H-4005-GMP, 4008614
 

Bachem Regulatory Documentation

CEP, DMF

Synonyms

GnRH; Gonadotropin-Releasing Hormone; LHRH; Luliberin;
Luteinizing Hormone-Releasing Factor

Sequence

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ acetate salt

Fields of Application

Ovarian follicular cysts (veterinary medicine)
Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)

Active Substance

Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.