What is enzymatic ligation and what are the benefits?
Oligonucleotide therapeutics are becoming increasingly complex, pushing traditional manufacturing methods to their limits. As researchers develop longer sequences with sophisticated modifications, a new approach is gaining prominence: enzymatic ligation. This...
Key challenges in AAD sourcing: GMP compliance, supply reliability & quality control
Amino acid derivatives (AADs) are essential starting materials for solid-phase peptide synthesis, crucial for the development of peptide-based therapeutics in areas like oncology, metabolic disorders, and infectious diseases. As the peptide therapeutics market...
5 Conjugate Reactions Improving Oligonucleotide Delivery
Oligonucleotides (oligos) are short strands of DNA or RNA that look set to revolutionize the treatment of a range of conditions from cardiovascular diseases to cancers and central nervous system disorders (CNS). Oligos are able to modulate gene expression in a number...
FMEA: A process for risk assessment in the pharmaceutical industry
The pharmaceutical industry operates under strict regulations to protect patient safety and maintain high-quality standards. Even small mistakes in drug development or manufacturing can lead to serious consequences, from costly recalls to potential harm. That’s why...