Content Type: Case Study

21 September 2026

Case study: Scale siRNA manufacturing efficiently via a fragment and enzymatic ligation approach

As demand for siRNA therapeutics continues to grow, manufacturers face increasing pressure to deliver larger quantities of drug…

03 August 2026

Case study: Verification of SAX method selectivity using 2D-LC-MS for peak purity assessment of oligonucleotide APIs

Accurate analytical characterization is essential throughout oligonucleotide development, supporting impurity profiling, stability assessment, and ultimately the delivery of…

11 June 2026

Stirring Things Up: Integrating Stirred-Bed SPOS and Enzymatic Ligation for Industrial Oligonucleotide Production

    The rising demands for therapeutic oligonucleotides requires scalable, efficient, and more sustainable manufacturing solutions. Stirred bed…

30 March 2026

Linear vs Fragment SPPS for Peptide Manufacturing

As demand for complex peptide APIs reaches unprecedented scales, manufacturers face a critical strategic question: is linear solid-phase…

18 February 2026

Webinar Evaluation of linear SPPS vs. conjugation of SPPS-based fragments

About the webinar As demand for peptide-based APIs grows, selecting the most efficient and cost-effective manufacturing route is critical.…

20 May 2025

Risk management in clinical trials: A case study in API production

Developing a peptide or oligonucleotide therapy requires more than scientific innovation, it demands a robust chemistry, manufacturing, and…

16 October 2024

Leading The Octreotide Scale-Up

Discover how Bachem revolutionized the production of octreotide acetate, a critical therapeutic peptide used in treating acromegaly. Our…

16 October 2024

Greener purification at large-scale, an oligonucleotide case study

Resembling a new era of innovative drug development, the interest of the biopharma industry in the oligonucleotide markets…

16 October 2024

Reducing solvent consumption for large-scale Peptide API manufacturing

Resembling a new era of innovative drug development, the interest of the biopharma industry in the peptide and…

11 May 2022

CMC Development of Peptides, A Case Study

An effective CMC strategy for any peptide API should include risk mitigation approaches suitable for the intended clinical…