BUSERELIN

Buserelin

H-4224-GMP, 4038785
 

Bachem Regulatory Documentation 

DMF

Synonym

(Des-Gly¹⁰,D-Ser(tBu)⁶,Pro-NHEt⁹)-LHRH

Sequence

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt
acetate salt

Fields of Application

Use in reproduction medicine
Advanced hormone-dependent prostate cancer
Endometriosis
Central precocious puberty
Uterine myoma

Active Substance

Buserelin is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of buserelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.