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Bachem AG Bachem Americas, Inc. Bachem Japan K.K.
Hauptstrasse 144 3132 Kashiwa Street Ueno Bldg, 8F
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA 1-9-10 Nihonbashi-Horidome cho, Chuo-ku
Tel +41 58 595 2021 Tel +1 888 422 2436 Tokyo 103-0012 - Japan
Fax +41 58 595 2040 Tel +1 888 4BACHEM Tel +81 3 6661 0774
Email Fax +1 310 539 9428 Email


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Scientific Research

Internal research projects at Bachem are primarily targeted to result in long-term commercial benefit. The continuous investment in development and implementation of new chemistries and technologies is regarded as crucial for future success. Especially, since stringent requirements from authorities and the demand for more complex structures from clients require major efforts to remain competitive. In particular, the increasing interest in longer and significantly more complex organic molecules like peptides and oligonucleotides represents a challenge for all manufacturers. Unlike biotechnological production, the synthetic access to these macromolecules allows for substantial fine-tuning of these structures. As a consequence, products with tailored properties can be developed, offering opportunities to achieve patent protection for the optimized structures.


This is in line with the requirements of the biotech- and pharmaceutical industries for more selective and potent medicines. In addition, ongoing research in proteomics continues to generate an incredible amount of knowledge regarding proteins and peptides derived thereof.


The enhanced interest in long peptides and even synthetic proteins is a logical consequence of this development. In particular, the progress in mass spectrometric techniques has facilitated the discovery of more complex peptides, and as considerable progress in synthesis and ligation technologies has been realized, these molecules are well within the scope of current synthetic methodologies. Bachem’s research projects originate from the idea to continuously evaluate new chemistries and technologies to improve on existing processes in a dynamic fashion.


Collaborations with external research institutions like the University of Basel are thought to complement these activities. At the University of Basel, Bachem sponsors the Bachem professorship for peptide chemistry since 1999, both to support research in peptide chemistry, and to encourage young talent in this area of organic chemistry.


Oligonucleotides can act on molecules, which otherwise would not be accessible for drugs. They can be designed to manipulate, silence or modulate defect genes. As technologies and know-how of the field are increasing, the ability to apply oligonucleotide therapies is undergoing dramatic growth. Oligonucleotides can be designed to treat single patients up to huge patient populations.


In order to support this development, we established a GMP manufacturing unit for oligonucleotide APIs, supported by a team of experts from oligonucleotide synthesis, R&D and other fields.