More sustainable Manufacturing of Peptides with MCSGP

Sustainable Chemistry UK Congress, Day One - 30th March 2023, 8:50 - 9:20 am

The main advantages of large-scale multi-column countercurrent solvent gradient purification (MCSGP) over other purification methods are its ability to achieve high purity and yield of the final product, while also reducing solvents, waste, and operation time. That’s why Bachem as a leading manufacturer of peptide active pharmaceutical ingredients (APIs) established large-scale MCSGP ready for further use in the GMP production of peptide APIs. Ralf Eisenhuth will take you on a journey from starting with small-scale MCSGP experiments in 2017 up to today’s large-scale MCSGP purification at Bachem. He will share data from process development and manufacturing, as well as insights on control strategies and the process mass intensity of MCSGP processes.

Ralf Eisenhuth

Principal Scientist - Process Manager Chromatography

Ralf Eisenhuth is a highly experienced and accomplished Principal Scientist at Bachem, the leading CDMO for the manufacture of peptide-based drugs. With a PhD in organic chemistry from the University of Karlsruhe (KIT), Dr. Ralf Eisenhuth joined Bachem AG in 2008. Over the last decade, he held several positions at Bachem; ranging from process development to leading the large-scale purification of peptides at the Bubendorf site. In his current position he is focusing on innovative purification technologies and processes.