Solubility-directed Development of Trileucine Process

The excipient Trileucine is applied for improving aerosol performance and stability of spray-dried powders for inhalation. At Bachem an LPPS manufacturing process for Trileucine has already been established yielding high quality material.

To allow the application of Trileucine also for aqueous solutions at neutral pH, further development work was performed to enhance the water solubility of the isolated peptide. This was successfully achieved by spray drying, but in a more straightforward way the Trileucine form with higher solubility in water could also be directly obtained by an improved crystallization process based on the results of a polymorph screening study.

To learn more about this development approach as well as about Trileucine properties, manufacturing, and application in general, watch the recording from our webinar on the solubility-directed development of the Trileucine manufacturing process.

Speakers

Wolfgang Seufert, Ph.D.

Director of Production at Bachem AG, The Peptide Easy Clean (PEC) Technology

Dr. Wolfgang Seufert is a Director of Production at Bachem Bubendorf facility. At Bachem he is leading a team focusing on the scale-up development of manufacturing processes for peptides in solution. Having joined Bachem more than 13 years ago and working in several positions at the Bubendorf and Torrance facilities of Bachem, he has gained broad experience in development, scale up, and manufacturing of peptides, both LPPS and SPPS. Wolfgang Seufert studied chemistry in Germany at the universities of Giessen and Leipzig. After earning his PhD from the University of Basel (Switzerland) for his work on cyclization reactions of modified amino acids and peptides, he worked as a post-doctoral fellow at the Life Sciences Institute of the University of Michigan (USA).

Moderator

Laura Milbrandt

Business Development Manager

Laura Milbrandt is an experienced Business Development professional with strong scientific, organizational, communication, and project management skills. She has gain a working knowledge of drug development pipelines and strategies specifically in immunology, oncology and rheumatology. Additioanlly, Laura provides a great familiarity with FDA, EMA, USP, ICH and cGMP guidelines and associated regulatory filings.