GOSERELIN ACETATE

Goserelin Acetate

4141427

Bachem Regulatory Documentation

CEP, DMF

Synonym

(D-Ser(tBu)⁶,Azagly¹⁰)-LHRH

Sequence

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH₂
acetate salt

Fields of Application

Advanced hormone-dependent prostate cancer
Advanced hormone-dependent breast cancer
Endometriosis
Uterine myoma
Use in reproductive medicine

Active Substance

Goserelin Acetate is a potent GnRH (LHRH) agonist. After a transient increase, continuous administration of goserelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

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Molecular Formula
C₅₉H₈₄N₁₈O₁₄

Relative Molecular Mass
1269.43 g/mol

CAS-Number
65807-02-5 (net), 145781-92-6 (acetate)

Long-term Storage
-20 ± 5°C

Also available

Related Research Grade Peptides

4038252	(D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (Goserelin)
4039400	(Des-Gly¹⁰,D-Ser(tBu)⁶,Pro-NHNH₂⁹)-LHRH (Decarbamoylgoserelin) Impurity E of the Goserelin Ph. Eur. monograph
4035303	(D-His²,D-Ser(tBu)⁶,Azagly¹⁰)-LHRH ((D-His²)-Goserelin) Impurity G of the Goserelin Ph. Eur. monograph
4047922	(D-Ser⁶,Azagly¹⁰)-LHRH ((D-Ser⁶)- Goserelin)
4054732	(Ser(Ac)⁴,D-Ser(tBu)⁶,Azagly¹⁰)-LHRH ((Ser(Ac)⁴)-Goserelin) Impurity K of the Goserelin Ph. Eur. monograph
4035307	(Ser(tBu)⁶,Azagly¹⁰)-LHRH ((Ser(tBu)⁶,Azagly¹⁰)-Goserelin) Impurity B of the Goserelin Ph. Eur. monograph

4035304	(D-Ser⁴,D-Ser(tBu)⁶,Azagly¹⁰)-LHRH ((D-Ser⁴)-Goserelin) Impurity A of the Goserelin Ph. Eur. monograph
4037082	(D-Ser(tBu)⁶,D-Leu⁷,Azagly¹⁰)-LHRH ((D-Leu⁷)-Goserelin)) Impurity L of the Goserelin Ph. Eur. monograph
4035302	(D-Tyr⁵,D-Ser(tBu)⁶,Azagly¹⁰)-LHRH ((D-Tyr⁵)-Goserelin) Impurity F of the Goserelin Ph. Eur. monograph

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