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Bachem AG Bachem Americas, Inc. Bachem Japan K.K.
Hauptstrasse 144 3132 Kashiwa Street Ueno Bldg, 8F
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA 1-9-10 Nihonbashi-Horidome cho, Chuo-ku
Tel +41 58 595 2021 Tel +1 888 422 2436 Tokyo 103-0012 - Japan
Fax +41 58 595 2040 Tel +1 888 4BACHEM Tel +81 3 6661 0774
Email sales.ch@bachem.com Fax +1 310 539 9428 Email sales.jp@bachem.com
  E-mail sales.us@bachem.com  

NP MARCH 2016

BACHEM  PIONEERING  PARTNER  FOR PEPTIDES
 NEW PRODUCTS ALERT
March 2016 EDITION
 

Now available @shop.bachem.com

Bachem is continuously expanding and updating its extensive range of products for your research purposes. 

We are pleased to present our latest products:

Alzheimer's Disease Related Products
 
H-8146Amyloid β-Protein (1-42) TFA Salt
H-7666FITC-εAhx-Amyloid β-Protein (1-42)
H-7686(Des-Glu²²)-Amyloid β-Protein (1-42)
The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.
H-7664Amyloid β-Protein (1-40) amide
H-7662(Arg¹³)-Amyloid β-Protein (1-40)
H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
H-7728Amyloid β-Protein (40-1)
Inactive control
H-7656Amyloid β-Protein (1-24)
H-7672Amyloid β-Protein (3-40)
H-7668Amyloid β-Protein (11-42)
H-7658
 
Acetyl-(N-Me-Leu¹⁷,N-Me-Phe¹⁹)-
Amyloid β-Protein (16-20) amide
Membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis.
H-7674
 
Amyloid Precursor Frameshift
Mutant C-Terminal Peptide
The sequence RGRTSSKELA corresponds to human APP frameshift mutant (339-348). RGRTSSKELA is used for generating antibodies.
H-7762Galanin (human)
Galanin has been shown to inhibit acetylcholine release, glutamate release and carbachol-stimulated phosphatidylinositol hydrolysis in the hippocampus. The peptide hormone is also linked to behavioral and cognitive deficits in Alzheimer's disease.
H-7604TRAF6 Peptide
The cell-permeable peptide inhibits the interaction of TRAF6, an E3 ubiquitin ligase, with p62 (sequestosome 1). P62 has been shown to be a polyubiquitin shuttling factor which binds to K63-polyubiquitinated proteins. TRAF6-p62 interaction modulators may be used to treat neuropathologies such as Alzheimer's disease or Huntington's disease. For a control peptide see H-7606.
H-7606TRAF6 Control Peptide
Inactive control for the TRAF6-p62 interaction modulator H-7604, the sequence differs in three positions.
C-42751,3-Bis-(Z-Leu-Leu)-diaminoacetone
(Z-LL)₂ Ketone, cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC₅₀ ca. 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasome.

Further Peptides
 
Uroguanylin
H-8142Uroguanylin Topoisomer B (human)

Building Blocks
 
Cysteine-containing Pseudoproline Dipeptides
Ser and Thr pseudoproline dipeptides play a crucial role in Fmoc-SPPS. The corresponding Cys derivatives broaden the scope of pseudoproline application, especially as cysteine can be desulfurated yielding alanine.
2,4-dimethoxyphenyl(Dmp)-thiaproline is compatible with standard Fmoc/tBu protocols and can be cleaved with 80% TFA in DCM.
B-4365Fmoc-Ala-Cys(Psi(Me,Me)pro)-OH
B-4395Fmoc-Gly-Cys(Psi(Dmp,H)pro)-OH
B-4400Fmoc-Leu-Cys(Psi(Dmp,H)pro)-OH
B-4405Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)pro)-OH
B-4410
 
Fmoc-Val-Cys(Psi(Dmp,H)pro)-OH
 
F-4290H-β-Cyclohexyl-Ala-OMe · HCl
A-4785Boc-Cys(StBu)-OH
StBu is cleaved by mercaptans, phosphines and other reducing agents. As it is stable towards TFA it is suitable for Boc-SPPS.
 
B-4445Fmoc-Cys(NPys)-OH
Npys allows site-directed disulfide bond formation, as it is cleaved by thiols.
 
B-4465Fmoc-His-OMe
B-4505Fmoc-Lys(palmitoyl-Glu-OtBu)-OH

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Contact Us

Europe, Africa, Middle East and Asia Pacific:
Bachem AG
Tel: +41 58 595 2020

sales.ch@bachem.com

Americas:
Bachem Americas, Inc.
Toll Free (USA and Canada): +1 888 422 2436 or Tel: +1 310 539 4171

sales.us@bachem.com

Visit our website at www.bachem.com
or shop online at shop.bachem.com.
 

All information is compiled to the best of our knowledge. We cannot be made liable for any possible errors or misprints.
Some products may be restricted in certain countries.

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