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Bachem AG Bachem Americas, Inc. Bachem Japan K.K.
Hauptstrasse 144 3132 Kashiwa Street Ueno Bldg, 8F
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA 1-9-10 Nihonbashi-Horidome cho, Chuo-ku
Tel +41 58 595 2021 Tel +1 888 422 2436 Tokyo 103-0012 - Japan
Fax +41 58 595 2040 Tel +1 888 4BACHEM Tel +81 3 6661 0774
Email sales.ch@bachem.com Fax +1 310 539 9428 Email sales.jp@bachem.com
  E-mail sales.us@bachem.com  

PRODUCT MONOGRAPHS

Bachem offers for free a series of brochures on selected groups of products in peptide research and detailed manuals on peptide synthesis.

Product Monographs

Amyloid Peptides
Extracellular amyloid-β peptide deposition into cerebellar plaques and formation of intracellular neurofibrillary fibers accompanied by the loss of neurons are characteristic histopathological lesions found in the brains of Alzheimer‘s disease patients. Individuals suffering from this disease show a gradual loss of cognitive functions and disturbances in behavior. Apart from some rare familial forms of the disease, the onset of Alzheimer‘s disease is usually above 60 years. Since the risk to develop the disease increases with age, Alzheimer‘s disease has become a major health and social problem in the developed countries with an increasing proportion of older people. In this brochure we present amyloid peptides and related products for Alzheimer‘s disease research.
(pdf, 2 MB) Bachem
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Antimicrobial Peptides
Ribosomally synthesized antimicrobial peptides (AMPs) constitute a structurally diverse group of molecules found virtually in all organisms. Most antimicrobial peptides contain less than 100 amino acid residues, have a net positive charge, and are membrane active. They are major players in the innate immune defense but can also have roles in processes as chemokine induction, chemotaxis, inflammation, and wound healing. In addition to their antimicrobial effects, many of them show antiviral and antineoplastic activities.
(pdf, 808 KB) Bachem
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Antimicrobial Peptides (Chinese Version)
Ribosomally synthesized antimicrobial peptides (AMPs) constitute a structurally diverse group of molecules found virtually in all organisms. Most antimicrobial peptides contain less than 100 amino acid residues, have a net positive charge, and are membrane active. They are major players in the innate immune defense but can also have roles in processes as chemokine induction, chemotaxis, inflammation, and wound healing. In addition to their antimicrobial effects, many of them show antiviral and antineoplastic activities.
(pdf, 942 KB)
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Antimicrobial Peptides (Japanese Version)
Ribosomally synthesized antimicrobial peptides (AMPs) constitute a structurally diverse group of molecules found virtually in all organisms. Most antimicrobial peptides contain less than 100 amino acid residues, have a net positive charge, and are membrane active. They are major players in the innate immune defense but can also have roles in processes as chemokine induction, chemotaxis, inflammation, and wound healing. In addition to their antimicrobial effects, many of them show antiviral and antineoplastic activities.
(pdf, 1 MB)
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Cell permeable Peptides
Cell-penetrating peptides (CPPs) constitute a promising tool for the cellular import of drug cargos. They have been successfully applied for in vitro and in vivo delivery of a variety of therapeutic molecules including plasmids, DNA, oligonucleotides, siRNA, PNA, proteins, peptides, low molecular weight drugs, liposomes, and nanoparticles.
(pdf, 2 MB)
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Click Chemistry
Bachem highlights the importance of “click reactions” in peptide chemistry as a simple and versatile concept for peptide synthesis and chemoselective modification. The broad spectrum of applications of the reaction includes ligation, cyclization, bio-conjugation, and radiolabeling of peptides.
(pdf, 356 KB)
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Cosmetic Peptides
Peptides are involved in many physiological processes. Their broad acceptance as natural molecules, relatively high stability and welldefined actions have made them attractive for many skin-related indications, most notably in anti-aging therapy. The aging population and their prevalent wish to keep a young and healthy appearance have substantially driven the development of anti-aging products. Many peptides marketed in cosmetic products are advertised to slow down or even reverse the aging process of the skin. Common modes of action include stimulation of collagen synthesis and inhibition of neurotransmitter release in order to reduce fine lines and wrinkles caused by the repetitive muscular activities of facial expression. We have considerable expertise and long-standing experience in peptide synthesis. With our capacity to upscale the production of simple and modified peptides, we are the partner of choice for the pharmaceutical and cosmetic industries.
(pdf, 711 KB)
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Cosmetic Peptides (Chinese Version)
Peptides are involved in many physiological processes. Their broad acceptance as natural molecules, relatively high stability and welldefined actions have made them attractive for many skin-related indications, most notably in anti-aging therapy. The aging population and their prevalent wish to keep a young and healthy appearance have substantially driven the development of anti-aging products. Many peptides marketed in cosmetic products are advertised to slow down or even reverse the aging process of the skin. Common modes of action include stimulation of collagen synthesis and inhibition of neurotransmitter release in order to reduce fine lines and wrinkles caused by the repetitive muscular activities of facial expression. We have considerable expertise and long-standing experience in peptide synthesis. With our capacity to upscale the production of simple and modified peptides, we are the partner of choice for the pharmaceutical and cosmetic industries.
(pdf, 2 MB)
Download
Cosmetic Peptides (Japanese Version)
Peptides are involved in many physiological processes. Their broad acceptance as natural molecules, relatively high stability and welldefined actions have made them attractive for many skin-related indications, most notably in anti-aging therapy. The aging population and their prevalent wish to keep a young and healthy appearance have substantially driven the development of anti-aging products. Many peptides marketed in cosmetic products are advertised to slow down or even reverse the aging process of the skin. Common modes of action include stimulation of collagen synthesis and inhibition of neurotransmitter release in order to reduce fine lines and wrinkles caused by the repetitive muscular activities of facial expression. We have considerable expertise and long-standing experience in peptide synthesis. With our capacity to upscale the production of simple and modified peptides, we are the partner of choice for the pharmaceutical and cosmetic industries.
(pdf, 2 MB)
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Cysteine Derivatives
Cystine disulfide bridges help to stabilize the biologically active conformation of peptides and proteins. They are generated by incorporation of cysteine residues followed by oxidation of the thiol functions yielding disulfides („folding“). For the chemical synthesis of peptides, a range of protecting groups has been developed for blocking these sensitive moieties which may be removed either directly before or during oxidative folding. When synthesizing peptides containing two or more disulfide bonds, S-protection may have to be varied to allow consecutive bridge formation for obtaining an unambiguous structure.
(pdf, 598 KB) Bachem
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