L-Norleucine (Nle) is a stable isostere of L-methionine. If sulfoxide formation reduces the biological activity of a peptide, Nle can be inserted as a substitute for Met, usually without altering its behavior.
Mar 18, 2021
L-Norleucine (Nle) is a stable isostere of L-methionine. If sulfoxide formation reduces the biological activity of a peptide, Nle can be inserted as a substitute for Met, usually without altering its behavior.
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