Which resins allow obtaining fully protected peptides?

Mar 16, 2021

Resins suitable for Fmoc-SPPS of protected peptides:

  • SASRIN (2-methoxy-4-alkoxybenzyl alcohol resin) and 2-Chlorotrityl resin
  • Xanthenyl linker resin (for protected peptide amides)
  • SASRIN-carbazate (for protected peptide hydrazides)

Bachem does not offer resins specifically designed for the Boc-SPPS of protected peptides. Such peptides can also be obtained by Boc-SPPS on e.g. Merrifield resin followed by cleavage with nucleophiles.