Resins suitable for the Fmoc-SPPS of “peptide acids” (i.e. C-terminal carboxyl group):

Wang resin (4-alkoxybenzyl alcohol resin), SASRIN (2-methoxy-4-alkoxybenzyl alcohol resin), 2-chlorotrityl chloride resin. As esterification of the C-terminal Fmoc-amino acid can be accompanied by concomitant racemization, we recommend using preloaded resins. They are produced under conditions optimized for minimal racemization and tested for chiral purity.

Resins suitable for the Fmoc-SPPS of peptide amides:

Fmoc-Rink amide AM resin (Fmoc-2,4-dimethoxy-4′-(carboxymethyloxy)-benzhydrylamine linked to Aminomethyl resin), Tricyclic amide linker resin, PAL resin (4-Alkoxy-2,6-dimethoxybenzylamine resin), Xanthenyl linker resin (Sieber amide resin). As removal of Fmoc and loading of the C-terminal amino acid can be easily included in standard Fmoc-SPPS protocols, we do not offer preloaded amide resins.