Which resins can be used for the synthesis of peptide acids?

Mar 16, 2021

Resins suitable for Fmoc-SPPS:

Wang resin (4-alkoxybenzyl alcohol resin), SASRIN (2-methoxy-4-alkoxybenzyl alcohol resin), 2-chlorotrityl chloride resin.

Resins suitable for Boc-SPPS:

Merrifield resin (chloromethyl resin) and hydroxymethyl resin, PAM (phenylacetamidomethyl) resin (only available in preloaded form)

As esterification of the C-terminal amino acid can be accompanied by concomitant racemization, we recommend using preloaded resins. They are produced under conditions optimized for minimal racemization and tested for optical purity.