04 February 2025
List of abbreviations
Below is a comprehensive list of abbreviations used throughout our peptide guide, covering analytical methods, chemical compounds and key terminology relevant to peptide synthesis and analysis. For abbreviations related to the 20 proteinogenic amino acids and common sidechain protecting groups, please refer to Tables 3 (Chapter 1) and 10 (Chapter 2).
| List of abbreviations | |||
|---|---|---|---|
| AAA | Amino acid analysis | Hyp | Hydroxyprolyl |
| Aad | α-Aminoadipyl | KLH | Keyhole limpet hemocyanin |
| ADS | Analytical Data Sheet | LHRH | Luteinizing hormone-releasing hormone |
| AMC | 7-Amido-4-methylcoumarin | MS | Mass spectrometry |
| API | Active pharmaceutical ingredient | MSG | Monosodium glutamate |
| Asu | α-Aminosuberyl | NAAG | N-Acetyl-Asp-Glu |
| Asx | Asn or Asp (in AAA) | NCL | Native chemical ligation |
| Boc | t-Butyloxycarbonyl | Nle | Norleucyl |
| BSA | Bovine serum albumin | NMP | N-Methylpyrrolidone |
| BSE | Bovine spongiform encephalopathy | NPC | Net peptide content |
| Bzl | Benzyl | Orn | Ornithyl |
| CCD | Countercurrent distribution | OVA | Ovalbumin |
| cGMP | Current good manufacturing practice | Pam | Palmitoyl |
| CHA | Cyclohexyl ammonium | PBS | Phosphate-buffered saline |
| CofA | Certificate of Analysis | PEG | Polyethylene glycol |
| Dab | α,γ-Diaminobutyryl | Ph. Eur. | European Pharmacopoeia |
| Dap | α,β-Diaminopropionyl | pNA | 4-Nitroanilide |
| DCHA | Dicyclohexylammonium | PTH | Parathormone |
| DMF | Dimethylformamide | Pyr | Pyroglutamyl |
| DMSO | Dimethylsulfoxide | RP-HPLC | Reversed-phase high-performance liquid chromatography |
| DOTA | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid | RSLC | Rapid separation liquid chromatography |
| DTPA | Diethylenetriaminepentaacetic acid | SPPS | Solid-phase peptide synthesis |
| DTT | 1,4-Dithio-dl-threitol | tBu | t-Butyl |
| FITC | Fluorescein isothiocyanate | TFA | Trifluoroacetic acid |
| Fmoc | 9-Fluorenylmethyloxycarbonyl | TLC | Thin-layer chromatography |
| FRET | Fluorescence resonance energy transfer | TRH | Thyrotrophin-releasing hormone |
| Glx | Gln or Glu or Pyr (in AAA) | TSE | Transmissible spongiform encephalopathy |
| GMP | Good manufacturing practice | TSH | Thyrotrophin-stimulating hormone |
| GnRH | Gonadotropin-releasing hormone | Xaa | Unspecified α-amino acid |
| HPLC | High-performance liquid chromatography | Yaa | Unspecified α-amino acid |
