Welcome to The Online Peptide Guide for Beginners, created by Bachem. As a global leader in contract development and manufacturing, we specialize in peptides, oligonucleotides, and small molecules, delivering tailored solutions to meet your needs. This guide gives you an introduction to peptide design, synthesis, and handling – designed for students, researchers, and collaborators.
What information will be covered within our peptide guide?
Our peptide guide covers essential topics like peptide synthesis methods (SPPS, LPPS, CEPS), purification techniques including MCSGP, and peptide modifications. It also explores quality control, custom peptide design, and best practices for handling peptides to ensure optimal results in your research and development projects.
Who is our online peptide guide best suited for?
This guide serves as an essential resource for researchers, university students, collaborators, and new team members, offering a concise introduction to peptide design, synthesis, and handling.
Whether you’re advancing groundbreaking research or exploring therapeutic innovation, Bachem is here to support your onward journey in the dynamic world of peptides. Explore career opportunities with Bachem and become part of a community of world-class professionals with unparalleled chemical knowledge and a shared passion for innovation.
The Peptide Guide: Choose Your Chapter
Peptides & Amino Acids
for Beginners
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We’ll cover the basics of peptides, their importance, and applications. You’ll learn about amino acids, their structure, and how they influence peptide properties. We’ll also explain amino acid notations and derivatives, providing the foundation for understanding peptide synthesis and its role in various industries.
Peptide Manufacturing
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In this section, we’ll explore the fundamentals of peptides, including their definition and significance. We’ll also delve into amino acids, examining their structures and how these influence the properties of peptides. Additionally, we’ll cover the notations used for amino acids and discuss their derivatives.
Introduction to Peptide Synthesis Methods
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This section explores four peptide synthesis methods: Solid-Phase Peptide Synthesis (SPPS), Liquid-Phase Peptide Synthesis (LPPS), Molecular Hiving™, and Chemo-enzymatic Peptide Synthesis (CEPS). Discover how Bachem employs these techniques, combining traditional methods with innovative approaches developed through industry partnerships.
Peptide Purification Process & Methods
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Bachem outlines the peptide purification process, including impurity removal, standard RP-HPLC purification, and alternatives for challenging peptides. It addresses scalability using methods like CCD, the impact of basic groups on salt formation, and introduces MCSGP technology, offering improved efficiency, sustainability, and higher yields in peptide manufacturing.
Quality Control of Amino Acids and Peptides
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This chapter focuses on the quality control (QC) processes for peptide products post-purification and lyophilization. It covers methods to confirm product identity, purity, and content, including techniques like TLC, HPLC, and mass spectrometry. It also addresses batch variability, handling of residual contaminants, and recommended purity levels for different applications.
What Is Peptide Modification?
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Read about how peptide modifications can enhance stability, functionality, and biological activity. Discover key techniques for N-terminal, side chain, and C-terminal modifications, and learn how these changes can optimize your peptide synthesis for specific applications. Explore the full range of possibilities for peptide modifications here.
Handling and Storage Guidelines for Peptides
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Read about the best practices for handling and storing peptides, including how to maintain their stability during storage, proper techniques for solubilization, and the precautions to take when handling sensitive peptide types. Discover expert tips for reconstitution and storage conditions to preserve peptide integrity and function. Learn how to prevent oxidation and moisture absorption, and ensure your peptides remain viable for research and application.
List of Abbreviations
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A comprehensive list of abbreviations used throughout our peptide guide, covering analytical methods, chemical compounds and key terminology relevant to peptide synthesis and analysis.
Peptides are at the heart of cutting-edge research and innovative therapies, from NCE development to generics. At Bachem, we’re here to help you take your projects to the next level with top-quality peptides and expert support. Whether you’re advancing research or developing life-changing treatments, we provide the solutions you need to succeed.
Looking to build a career in peptides? We’re also always seeking talented individuals to join our innovative team. You’ll get to work alongside industry experts while advancing peptide science and therapeutic development. Visit our careers page to explore opportunities at Bachem or contact us today to learn more.
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