Webinar Evaluation of linear SPPS vs. conjugation of SPPS-based fragments

As demand for peptide-based APIs grows, selecting the most efficient and cost-effective manufacturing route is critical. In this webinar, we will compare linear Solid-Phase Peptide Synthesis (SPPS) with SPPS-based fragment conjugation, focusing on cost and scalability in large-scale production. Through a case study, modeling assumptions, experimental setups, and key efficiency parameters will be explored to guide informed decisions in optimizing peptide API manufacturing strategies.

About the Speakers

Pascal Engi, PhD
Senior Group Leader R&D

Pascal Engi studied chemistry at the University of Bern, Switzerland. He then joined the group of Prof. Florian Seebeck at the University of Basel, where he obtained his Ph.D. for designing and synthesizing modified peptide and amino acid probes to elucidate enzymatic mechanisms in 2017. In 2018 he started his career as project chemist with Bachem in Switzerland. Pascal took a position as team leader in the R&D department after a short while and later as senior group leader in the same department. During his time at Bachem he has been involved with many successful and challenging process development projects as well as GMP and non-GMP manufacturing campaigns.

Günter Pappenberger, PhD
Senior Product Leader

Günter has a degree in Biochemistry (1996) and a PhD in Biophysics (2000). Throughout his career, he has worked on proteins and peptides across various industries and applications. He joined Bachem in 2021 as CMC Project Leader and has supported Bachem’s clients in the development and implementation of large-scale manufacturing processes for peptides. In his current role as Senior Product Leader, Günter is continuing to support Bachem’s clients throughout the life cycle of the product by ensuring its operational and commercial performance.