Molecule: Oligonucleotides

21 September 2026

Case study: Scale siRNA manufacturing efficiently via a fragment and enzymatic ligation approach

As demand for siRNA therapeutics continues to grow, manufacturers face increasing pressure to deliver larger quantities of drug…

11 September 2026

Different types of liquid chromatography explained

Liquid chromatography is one of the most widely used analytical techniques in pharmaceutical development. Almost every modern drug…

03 August 2026

Case study: Verification of SAX method selectivity using 2D-LC-MS for peak purity assessment of oligonucleotide APIs

Accurate analytical characterization is essential throughout oligonucleotide development, supporting impurity profiling, stability assessment, and ultimately the delivery of…

20 July 2026

API contract manufacturing: Process, benefits, and partner selection

Manufacturing active pharmaceutical ingredients (APIs) is a complex undertaking that requires specialized process knowledge, advanced manufacturing capabilities, and…

11 June 2026

Stirring Things Up: Integrating Stirred-Bed SPOS and Enzymatic Ligation for Industrial Oligonucleotide Production

    The rising demands for therapeutic oligonucleotides requires scalable, efficient, and more sustainable manufacturing solutions. Stirred bed…

21 May 2026

Webinar 2D LC/MS: Peak purity determination for denaturing SAX oligonucleotide methods

  About the webinar Oligonucleotides are emerging new therapeutic entities, and reliable selective analytical methods to determine their…

09 January 2026

Publications

Review the scientific articles where the Bachem team has contributed to peptide and oligonucleotide research. Symmetrical Branching Unit…

05 November 2025

The importance of time to market for New Chemical Entities

In the highly competitive pharmaceutical industry, time to market plays a pivotal role in determining the success of…

05 November 2025

Webinar Efficient Large-scale SiRNA Manufacturing: Enzymatic Ligation of Short RNA Fragments

  Linear synthesis by continuous-flow SPOS is the current state-of-the-art technology to manufacture oligonucleotide APIs. A very promising alternative,…