Molecule: Oligonucleotides

09 January 2026

Publications

Review the scientific articles where the Bachem team has contributed to peptide research and peptide synthesis. Process Characterization and…

05 November 2025

The importance of time to market for New Chemical Entities

In the highly competitive pharmaceutical industry, time to market plays a pivotal role in determining the success of…

05 November 2025

Webinar Efficient Large-scale SiRNA Manufacturing: Enzymatic Ligation of Short RNA Fragments

  Linear synthesis by continuous-flow SPOS is the current state-of-the-art technology to manufacture oligonucleotide APIs. A very promising alternative,…

08 October 2025

What is enzymatic ligation and what are the benefits?

Oligonucleotide therapeutics are becoming increasingly complex, pushing traditional manufacturing methods to their limits. As researchers develop longer sequences…

29 September 2025

Enzymatic ligation and other innovative technologies: Shaping the future of large-scale Oligonucleotide manufacturing

Oligonucleotide-based therapeutics are transforming modern medicine, offering targeted solutions for genetic disorders, cancer, cardiovascular disease, and CNS conditions.…

05 September 2025

5 Conjugate Reactions Improving Oligonucleotide Delivery

Oligonucleotides (oligos) are short strands of DNA or RNA that look set to revolutionize the treatment of a range…

24 June 2025

FMEA: A process for risk assessment in the pharmaceutical industry

The pharmaceutical industry operates under strict regulations to protect patient safety and maintain high-quality standards. Even small mistakes…

20 May 2025

Efficient Large-scale siRNA Manufacturing: Enzymatic Ligation of Short RNA Fragments

  Linear synthesis by continuous-flow SPOS is the current state-of-the-art technology to manufacture oligonucleotide APIs. A very promising…

20 May 2025

Risk management in clinical trials: A case study in API production

Developing a peptide or oligonucleotide therapy requires more than scientific innovation, it demands a robust chemistry, manufacturing, and…

13 November 2024

New Trends In Oligotherapeutics

The oligotherapeutics market has expanded in size, disease indications and exploratory molecules in recent years, As oligo API…