Nowadays, SPPS (solid phase peptide synthesis) is the go-to method for peptide synthesis. It is a rapid, orthogonal and efficient process. SPPS is able to synthesize sets of peptides in parallel, while the go-to purification method, RP-HPLC, is a linear process and can represent the bottleneck of peptide development and manufacturing.
The new and innovative purification method introduced in this whitepaper extends the previous features of SPPS to the purification of peptides. The catch-and-release platform, termed Peptide Easy Clean, developed by Belyntic in collaboration with Bachem, enables the successful and innovative purification of peptides.