MEET US AT THE IBERIAN PEPTIDE MEETING
Click Chemistry Involving PeptidesClick chemistry provides a number of avenues for peptide or protein modifications and could be combined with other techniques to make complex structures and multi-component functionalized systems with ease. The chemistry can be performed in different ways. For example, peptides can be converted post-synthetically to an azido derivative which can be clicked with appropriate substrate containing a clickable alkynyl group or vice versa. Peptides can also be made by inter- and intramolecular click reactions using azide or alkyne containing amino acids or building blocks during peptide synthesis. Building blocks containing clickable moieties will be instrumental for constructing side-chain modified peptides, interside-chain peptide chimera, peptide small molecule conjugates, and cyclic peptides. Solid phase resins modified with clickable groups can also be used for making clickable or modified peptides. Click chemistry is compatible with various protected amino acid side chains used in peptide synthesis.
A number of reagents and building blocks can be used for click chemistry. These include ω-azido-α-amino acids, PEG and spacer azides and alkynes, azide- or alkyne-modified fluorescent dyes and quenchers, nucleosides and nucleotides, alkyne or azide-containing chemical modification reagents, diazo transfer reagents, and propargyl derivatives of amino acids (e.g.O-propargylserine, glutamic acid bispropargyl amide)
The most important applications of click chemistry in peptide science include chemical ligation, cyclization and bioconjugation (Figure 2). Other typical applications are conjugation of isotope labels for imaging, synthesis of peptidomimetics based on the triazole backbone, conformational and backbone modifications.
Figure 2: Utilization of click chemistry for ligation, cyclization and conjugation of peptides.
|Product Name||ADC Components||Pipeline Indication(s)||Highest Phase||Companies (Partner)|
|ARX788||HER2 targeting antibody + Amberstatin269||Ovarian Cancer, Esophageal Cancer, Adenocarcinoma Of The Gastroesophageal Junction, Pancreatic Cancer, Gastric Cancer, Metastatic Breast Cancer, Colon Cancer, Gastroesophageal (GE) Junction Carcinomas||Phase I||Ambrx; Zhejiang Medicine|
|TRPH-222||Anti-CD22 antibody + maytansine||Follicular Lymphoma, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma, Marginal Zone B-Cell Lymphoma||Phase I||Catalent/ Redwood Bioscience (Triphase Accelerator Corp)|
|STRO-001||Anti-CD74 IgG1 antibody (SP7219) + maytansine||Follicular Lymphoma, Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma, Refractory Multiple Myeloma, Relapsed Multiple Myeloma||Phase I||Sutro Biopharma|
|STRO-002||Anti-FolRa human IgG1 antibody (SP8166) + 3-aminophenyl hemiasterlin||Fallopian Tube Cancer, Epithelial Ovarian Cancer, Endometrial Cancer, Peritoneal Tumor||Phase I||Sutro Biopharma|
|ADCT-601||Anti-AXL IgG1 antibody + Pyrrolobenzo-diazepine dimer SG3199||Breast Cancer, Ovarian Cancer, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Esophageal Cancer, Malignant Mesothelioma, Soft Tissue Sarcoma, Colorectal Cancer, Head And Neck Cancer, Pancreatic Cancer, Gastric Cancer||Phase I||Synaffix (ADC Therapeutics|
What is your official job title at Bachem?
My job title is Senior Chemist QC.
How long have you been with Bachem? Where did you work before Bachem?
I have been working at Bachem for 2 years now. I started as Project Chemist and became later Senior Chemist. Before Bachem, I did my Master’s Degree in Physical Chemistry at the ZHAW.
Briefly, what do you do at Bachem?
I work in the QC Late Phase department and I am responsible for method development (GC, IC, IR), qualification of instruments, supporting at troubleshooting, organizing and prioritizing different analysis and for the release of raw and starting materials.
What is your academic background/degrees or training?
The topic of my bachelor’s degree in nanotechnology was the synthesis and analysis of phosphorescent nanoparticles. The topic of my master’s degree in physical chemistry was the enantiomeric separation of small chiral molecules.
What do you like to do outside of work?
I enjoy spending my time in nature, being with my family and friends, doing sport (fitness, bouldering, skiing, snowboarding), cooking and travelling.
What do you like most about your job?
I like being involved in different projects, which makes my job very interesting and versatile. Besides that, I appreciate getting in contact with many different people from in- and outside of Bachem.
Thank you very much Manuela.
Interesting news about peptides in basic research and pharmaceutical development:
Is a universal vaccine against cancer possible?-Drug Target Review
Peptide catalyzes macrocycle formation-Chemical & Engineering News