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Figure 1: A. Catalytic gelation in discovery of catalytic peptides via phage display B. Peptide sequences selected by catalytic self-assembly combined with phage display. C. Turnover data for hydrolysis of p-nitrophenyl acetate by free peptides (based on a 10 minute time course).
Designer Peptide Nanostructures
Peptide self-assembly has always been an area that chemists have understood, but most of the important peptides have been found by serendipity. Molecular Dynamics is a powerful tool that can help predict the self-assembling nature of peptides while reducing the timescale to experimentally examine the properties. We implement coarse grain molecular dynamics on tripeptide systems to identify the aggregation propensity of the tripeptides.2 Using this prediction, experimental methods can be carried out on the most promising candidates to validate these nanostructures. Introduction of organic solvents has shown exciting observations where the prediction of stable emulsifiers can be achieved. We see sequence dependence for these tripeptides, which promote two classes of emulsifiers; traditional surfactant-like assemblies and interfacial nanofibrous networks, in which the latter allows for the formation of more robust and tunable emulsions.3
Figure 2: Schematic of tripeptide emulsion stabilisation A) Cartoon of the sequence dependence of the tripeptides B) FTIR of the Emulsion state C) Fluorescence microscopy of Emulsion stained with Sudan II D) Fluorescence microscope of fibrous assembly stained with Thioflavin T
 Frederix, P. W. et al Nat. Chem. 2014, 30. 30-37
 Scott, G. G. et al, Adv. Mat., 2015, accepted manuscript
Article by Adrienne Blevins Mendoza, American Peptide Company (A member of the Bachem Group)
The ISO 13485 Standard is a gold standard for Quality Management that is designed and tailored to meet the strict quality program demands manufacturers and suppliers of the Medical Device industry. ISO 13485 certification must be issued by an independent, accredited certification body that guarantees that the quality management system has been implemented, documented, used, maintained and improved by the organization in accordance with the specific ISO standard.
Key Benefits of ISO 13485 certification:
- Assurance that provided services and products must meet a high quality standard
- Increased operational effectiveness through standardized procedures
- Reduced production loss caused by failures in quality
- Reduced operational costs by increased process efficiency and reliability
- Increased customers’ trust in the organization as a safe supplier and a user of well accepted standards
The process for achieving ISO certification can be arduous, expensive, and time-consuming, and many organizations cannot complete the process. Organizations must perform a self-assessment and correct gaps to comply to ISO standards. The organization must provide examples and case-studies of how the organization has successfully implemented and benefited from the quality programs under the ISO Standards. After the self-assessment is complete, organizations must undergo a thorough evaluation of the quality program by an independent, accredited certification body. Any departures from the ISO Standards are not accepted, and must be resolved, and the correction must be demonstrated before certification can be issued.
Once the organization successfully achieves certification, it is continuously monitored through periodic surveillance and recertification audits that assess whether the organization continues to meet the ISO Standards. The organization must formally respond to any observations made during the audits, and these corrective actions are verified in subsequent audits by the certification body.
The Vista site celebrated their achievement in obtaining ISO 13485 certification in 2014 after overhauling the Quality Management System in order to comply with the high quality standards of the Medical Device Industry. ISO 13485 was chosen for its applicability to many of the site’s customers requiring Peptide for use in medical devices, and requiring that supplier quality programs are compliant to their own quality system requirements. The Vista site selected the world renowned and highly respected British Standards Institute (BSI) as the independent organization for certification, and can proudly display the BSI Assurance Mark.
What is your official job title at Bachem?
Director, Research Sales
How long have you been with Bachem? Where did you work before Bachem?
I have been working at Bachem Americas for 9 Years. I started as a Quality Control Scientist and have been in Sales Management since 2010. Prior to joining Bachem, I worked as a Postdoctoral researcher at the department of Biology, at the University of South Carolina
Briefly, what do you do at Bachem?
I manage the Inside Sales team. We are responsible for all sales activities as well as customer service and support for catalog and custom synthesis products in the US, Canada and Latin America.
What is your academic background/degrees or training?
I have a Ph.D. in Biology
What do you like to do outside of work (interests, hobbies)?
I enjoy reading, hiking, swimming and playing tennis.
How is the Marketing & Sales team partnering with their customers?
We try to understand the customer business needs and objectives, and offer tailored solutions. As an example, we offer support to our clients in terms of sequence design and selection of the appropriate product specifications depending on the intended use of the peptide.
What do you like most about your job?
Every customer project is an opportunity to explore and learn new things. In addition, I have the chance to work in close collaboration with colleagues across all functional areas.
What is your preferred peptide?
The antimicrobial peptide Defensin HNP-1 (human).
Thank you very much Loubna.