Carbidopa API manufacturer
Product Code: 4037809 Product Code GMP: 1610-GMP
Key Information
Regulatory Documentation
DMF: available
CEP: available
Chemical Identifiers
CAS Number(s):
- 28860-95-9 (net)
- 38821-49-7 (monohydrate)
Synonyms:
- α-Methyldopahydrazine
- (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid · H2O
- (S)-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate
- (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate
Sequence
n.a.
Fields of Application
Parkinson’s Disease
Active Substance
Carbidopa is a peripheral dopa-decarboxylase inhibitor which exhibits a distinct pharmacological activity only when given in combination with levodopa. Carbidopa inhibits the peripheral decarboxylation of levodopa to dopamine. As, unlike levodopa, carbidopa does not cross the blood-brain barrier, effective brain concentrations of dopamine are produced with lower doses of levodopa.
In the treatment of parkinsonism carbidopa is administered in combination with levodopa to allow a lower dosage of the latter, a more rapid onset of a response, and a mitigation of adverse effects.
Molecular Information
Molecular Formula:
C10H14N2O4 · H2O
Relative Molecular Mass:
226.23 g/mol (net) 244.25 g/mol (monohydrate)
Long-term Storage:
Room temperature
Why choose Bachem for your Carbidopa Supply
Proven API Expertise
Decades of experience in peptide and small‑molecule synthesis enable Bachem to deliver consistently high‑quality carbidopa.
GMP-certified Precision
Strict GMP compliance and rigorous quality control ensure every batch of carbidopa meets the highest regulatory and purity standards.
Secure, Reliable Supply
In‑house production of starting materials and robust inventory management safeguard your supply chain from disruptions.
Scalable Manufacturing Capacity
State‑of‑the‑art facilities support flexible order sizes—from grams to hundreds of kilograms—without compromising timelines.
Comprehensive Regulatory Support
Access to DMFs, CEPs, and expert regulatory guidance streamlines your approval processes and accelerates market readiness.
Customer-centric Partnership
Bachem’s responsive service, technical expertise, and tailored solutions create a dependable, long‑term API manufacturing partnership.
Driving Generic Drugs Together
Rely on our years of experience in manufacturing APIs for your next commercial drug venture.
Additional Information on Carbidopa
What is carbidopa?
Carbidopa is a medication often used alongside levodopa to help manage Parkinson’s disease. By working together, they improve the treatment of symptoms like tremors, stiffness, and slow movement. Carbidopa is particularly important because it enhances levodopa’s effectiveness while also reducing side effects such as nausea. This makes it easier for patients to tolerate their treatment and experience better overall results.
Carbidopa mechanism of action
Carbidopa primarily acts by inhibiting the enzyme aromatic L-amino acid decarboxylase, which is responsible for converting levodopa into dopamine outside the brain. By preventing this conversion in the peripheral tissues, carbidopa ensures that more levodopa reaches the brain intact, where it can be transformed into dopamine. This not only maximizes the therapeutic effect of levodopa but also reduces side effects associated with excess dopamine production in the body, such as nausea and vomiting. As a result, carbidopa enhances the overall efficacy of Parkinson’s disease treatment, helping to improve patients’ quality of life.
What is carbidopa used for?
Carbidopa is widely used to help manage symptoms of Parkinson’s disease when combined with levodopa. This combination is effective in reducing symptoms like tremors, stiffness, and slow movement, which can significantly impact daily life. By allowing more levodopa to reach the brain, carbidopa enhances its benefits while reducing common side effects, such as nausea, that often arise when levodopa is taken on its own.
In some cases, carbidopa is also used for other movement disorders with similar dopamine-related symptoms, making it a versatile choice for long-term symptom management.
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