Etomidate API manufacturer
Product Code: 4049295 Product Code GMP: 2990-GMP
Key information
Regulatory documentation
DMF: available
CEP: available
Chemical identifiers
CAS Number(s): 33125-97-2
Synonyms:
- 1-[(1R)-1-Phenylethyl]-1H-imidazole-5-carboxylic acid ethyl ester
- (+)-Ethyl 1-(α-methylbenzyl)imidazole-5-carboxylate
Sequence
n.a.
Fields of application
Anesthesia
Active substance
The imidazole derivative etomidate is a rapid, short-acting intravenous anesthetic agent. Etomidate, a GABA-A receptor agonist, acts as a sedative but not as an analgesic. A relative lack of significant hemodynamic and respiratory effects is a further reason for choosing etomidate for inducing anesthesia. Etomidate is applied as a sedative or anesthetic, especially in emergency medicine. The anesthetic has also been found in small animal veterinary practice.
Molecular information
Molecular formula:
C14H16N2O2
Relative molecular mass:
244.29 g/mol
Long-term storage:
Room temperature
Why choose Bachem as your Etomidate supplier
Trusted quality
We deliver high-purity etomidate manufactured in GMP-certified facilities that meet the most rigorous regulatory expectations.
Flexible supply
Production capabilities ranging from gram‑scale to multi‑kilogram batches ensure customers receive exactly the quantity they need on time.
Regulatory support
Comprehensive documentation, including DMFs and CEPs, simplifies regulatory submissions and reduces administrative burden for customers.
Process innovation
Continuous optimization and advanced technologies enable efficient manufacturing that shortens lead times and lowers overall costs.
Customer partnership
A dedicated team provides personalized guidance and tailored solutions, ensuring each client’s unique requirements are fully supported.
Reliable delivery
Robust operations and a customer‑centric approach guarantee a consistent, dependable supply of etomidate for diverse market needs.
Driving generic drugs together
Rely on our years of experience in manufacturing generic APIs for your next commercial drug venture.
Additional Information on Etomidate
What is etomidate?
Etomidate is a short-acting intravenous anesthetic frequently used for inducing general anesthesia. Its rapid onset and quick recovery make it especially suitable for patients with compromised cardiovascular health. The drug enhances the action of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, resulting in sedation and unconsciousness. Because etomidate has minimal impact on heart rate and blood pressure, it is considered a safe option for those needing fast sedation. However, due to possible side effects like adrenal suppression, etomidate is typically reserved for short procedures or used as part of a balanced anesthetic approach.
Etomidate mechanism of action
Etomidate exerts its anesthetic effects by modulating the activity of the GABA neurotransmitter system. Specifically, it enhances the binding of GABA to its receptors, particularly the GABA-A receptor, which increases the influx of chloride ions into neurons. This hyperpolarizes the cell membrane, leading to decreased neuronal excitability and resulting in sedation and unconsciousness. Due to its high lipid solubility, etomidate rapidly crosses the blood-brain barrier, allowing for swift onset of action. Its short duration of action is mainly attributed to the rapid redistribution of the drug from the brain to other tissues, which allows for a quick recovery following administration.
What is etomidate used for?
Etomidate is primarily used as an intravenous anesthetic for the induction of general anesthesia, particularly in settings where rapid onset and quick recovery are essential. Its unique pharmacological profile makes it a suitable choice for patients with cardiovascular instability, as it has minimal effects on heart rate and blood pressure.
In addition to its use in general anesthesia, etomidate is often employed for procedural sedation in emergency medicine and critical care settings, enabling rapid sedation for various procedures such as intubation or diagnostic imaging. It is also beneficial in patients at risk of hemodynamic complications due to its cardiovascular stability.
Etomidate is sometimes used for sedation in intensive care units (ICUs) when patients require brief periods of unconsciousness without significant hemodynamic effects. However, its use is typically limited to short-term sedation due to its potential to cause adrenal suppression with prolonged administration.
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