Tetracosactide API manufacturer
Product Code: 4042686 Product Code GMP: H-1150-GMP
Key information
Regulatory documentation
DMF: available
Chemical identifiers
CAS Number(s):
- 16960-16-0 (net)
- 60189-34-6 (acetate)
Synonyms:
- Cosyntropin
- Tetracosactrin
- α1-24-Corticotropin
- ACTH (1-24)
Sequence
H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH acetate salt
Fields of application
- Investigation of adrenocortical insufficiency
- Neurological diseases
- Rheumatic diseases
- Skin diseases
- Diseases of the intestinal tract
- Oncology
Active substance
Tetracosactide (cosyntropin) is a synthetic peptide corresponding to the N-terminal 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). Tetracosactide stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.
Molecular information
Molecular formula:
C136H210N40O31S
Relative molecular mass:
2933.48 g/mol
Long-term storage:
-20 ± 5°C
Why choose Bachem as your Tetracosactide API manufacturer
Peptide expertise
Bachem delivers tetracosactide backed by five decades of specialized Peptide‑synthesis experience, ensuring exceptional reliability and know‑how.
High purity
Our refined manufacturing processes consistently achieve outstanding purity profiles and reproducible yields for this complex 24‑amino‑acid Peptide.
Regulatory strength
Bachem provides comprehensive regulatory support, including current DMFs and CEPs, to streamline global development and approval pathways.
cGMP compliance
Production occurs in rigorously audited, fully cGMP‑compliant facilities using advanced analytical methods and strict quality controls.
Flexible supply
We accommodate both small research quantities and large‑scale commercial needs with adaptable manufacturing capacity.
Dedicated support
Customers benefit from personalized project management and transparent documentation, ensuring smooth collaboration from development to delivery.
Driving generic drugs together
Rely on our years of experience in manufacturing Peptide APIs for your next commercial drug venture.
Additional Information on Tetracosatide
What is tetracosactide/cosyntropin acetate?
Tetracosactide (also known as cosyntropin) acetate is a synthetic polypeptide that corresponds to the first 24 amino acids of the naturally occurring adrenocorticotropic hormone (ACTH). This synthetic analogue mimics the biological activity of natural ACTH, primarily stimulating the adrenal cortex to produce and release cortisol and other corticosteroids.
As a highly specific and potent ACTH analogue, tetracosactide acetate serves as a valuable tool in endocrine medicine for evaluating adrenal insufficiency and treating certain autoimmune conditions.
Tetracosactide acetate mechanism of action
Tetracosactide acetate functions by binding to melanocortin-2 receptors (MC2R) on the surface of adrenocortical cells in the adrenal glands. This binding initiates a signalling cascade that activates adenylate cyclase, leading to increased intracellular cyclic AMP (cAMP) levels. The elevated cAMP triggers protein kinase A activation, which ultimately results in the synthesis and release of corticosteroids, primarily cortisol. Additionally, it stimulates the production of other adrenal hormones including aldosterone and androgens.
The drug’s mechanism closely mirrors that of natural ACTH, making it particularly effective for both diagnostic testing of adrenal function and therapeutic applications.
What is tetracosactide used for?
Tetracosactide serves both diagnostic and therapeutic purposes in clinical medicine. Diagnostically, it is primarily used in the ACTH stimulation test (short synacthen test) to assess adrenal function and diagnose conditions such as Addison’s disease, congenital adrenal hyperplasia, and secondary adrenal insufficiency. The test evaluates the adrenal glands’ ability to respond to ACTH by measuring cortisol levels before and after administration.
Therapeutically, tetracosactide can be used to treat various medical conditions, including certain types of epilepsy, particularly West syndrome (infantile spasms) and Lennox-Gastaut syndrome. It is also used in managing some autoimmune and inflammatory conditions, where its ability to stimulate endogenous cortisol production can help reduce inflammation and modulate immune responses.
The drug has also proved to be very effective in specific cases of multiple sclerosis relapses, certain rheumatic conditions, and various inflammatory bowel diseases where conventional steroid therapy is not always suitable or effective.
In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.
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