Triptorelin Acetate & Pamoate

Peptide API Manufacturer

Triptorelin Acetate & Pamoate manufacturer

Acetate Product Code: 4008442 Product Code GMP: H-4075-GMP Pamoate Product Code: 4144950 Product Code GMP: H-4060-GMP

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Key information

Regulatory documentation

DMF: available

Chemical identifiers

CAS Number(s):

57773-63-4 (net)
140194-24-7 (acetate)
124508-66-3 (pamoate)

Synonyms:

Acetate:
- (D-Trp6)-LHRH
- (D-Trp6)-GnRH
Pamoate:
- (D-Trp6)-LHRH
Triptorelin Embonate
Triptorelina
Triptoreline

Sequence

Acetate: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂ acetate salt

Pamoate: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂ pamoate salt

Fields of application

After intramuscular injection, it briefly stimulates the pituitary gland to release LH and FSH—the signals that trigger testosterone and oestradiol production.

Active substance

Triptorelin is a synthetic analog of GnRH, a hormone naturally produced by the hypothalamus in the brain. GnRH plays a crucial role in regulating the production of sex hormones, specifically LH and FSH.

Molecular information

Molecular Formula:

C₆₄H₈₂N₁₈O₁₃

Relative molecular mass:

1311.47 g/mol

Long-term storage:

-20 ± 5°C

Discover how we use synergies to improve Triptorelin production

Find more relevant information on Goserelin, Leuprorelin and Triptorelin and our unique synthesis approach, that ensures economies of scale for API manufacturing.

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Why choose Bachem for Triptorelin Acetate & Triptorelin Pamoate

Deep GnRH expertise

With over 20 years of GMP grade experience in gonadorelin (LHRH) analogs, Bachem manufactures hundreds of kilograms of “relins” annually, ensuring unmatched process knowhow.

Optimized, efficient processes

Continuous process improvements enhance efficiency, robustness, and sustainability, giving customers high quality material with reliable performance.

Comprehensive regulatory support

Bachem provides extensive regulatory documentation, including DMFs and CEPs, along with expert guidance to accelerate global registrations.

Fast, flexible supply

Whether a few grams or tens of tons are needed, Bachem delivers quickly from stock and adapts to any scale of demand.

Secure, sustainable supply chain

Inhouse production of starting materials ensures supply security, traceability, and long-term sustainability.

Innovation driven quality

A strong innovation culture drives continuous improvements in technology, quality, lead times, and cost effectiveness across all generic APIs.

Shaping the Future

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Product Number	Name	Sequence	Salt
4029115	(Trp⁶)-Triptorelin	Pyr-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4033016	(D-Trp⁶)-GnRH, Triptorelin acetate salt, [DTrp6] LH-RH, amide	Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Acetate
4039648	Triptorelin pamoate salt	Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Pamoate
4026526	Triptorelin (free acid)	Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-OH	Trifluoroacetate
4029113	Triptorelin (1-6) amide	Pyr-His-Trp-Ser-Tyr-D-Trp-NH₂
4025364	(D-His²)-Triptorelin	Pyr-D-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4025363	(D-Ser⁴)-Triptorelin	Pyr-His-Trp-D-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4025366	(D-Leu⁷)-Triptorelin	Pyr-His-Trp-Ser-Tyr-D-Trp-D-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4025365	(D-Tyr⁵)-Triptorelin	Pyr-His-Trp-Ser-D-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4029114	Formyl-Triptorelin (2-10)	For-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4029116	Triptorelin-Leu-Arg-Pro-Gly-NH₂	Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate
4042497	(Des-Pyr¹,D-Trp⁶)-LHRH, (Des-Pyr¹)-Triptorelin	H-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂	Trifluoroacetate

Additional information on Triptorelin Acetate and Triptorelin Pamoate

Triptorelin is a synthetic agonist analog of gonadotropin-releasing hormone (GnRH), repressing the expression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). First approved in 1986, the indications include prostate cancer, uterine fibroids, central precocious puberty, endometriosis, female infertility, and breast cancer. Triptorelin is a short peptide consisting of nine amino acids.

What is triptorelin used for?

When triptorelin is applied as intramuscular injection, it initially stimulates the pituitary gland in the brain, much like natural GnRH. This stimulation prompts the pituitary gland to release LH and FSH, which are the messengers that signal the testes in males and the ovaries in females to produce sex hormones, such as testosterone and oestradiol.

Stimulation in the pituitary gland releases LH and FSH just like natural GnRH

However, as triptorelin injection treatment continues, a process known as “downregulation” occurs. This means that the pituitary gland becomes less responsive to the constant GnRH-like signals generated by triptorelin.

As a result of this desensitization, the production of LH and FSH by the pituitary gland decreases over time. Since LH and FSH are essential for stimulating the production of sex hormones, their reduction leads to a significant decrease in testosterone levels in males and oestradiol levels in females.

Ultimately, the diminished production of sex hormones leads to a state of hypogonadism, where the levels of testosterone or oestradiol in the body drops significantly below the normal range. This controlled reduction of sex hormones is the desired therapeutic outcome in various conditions. For example, in prostate cancer, lowering testosterone levels can slow the growth of cancer cells, while in conditions like endometriosis and uterine fibroids, it can reduce symptoms associated with excess oestradiol.

How is triptorelin administrated?

Triptorelin is available in two different salt forms, which are tritptorelin acetate and triptorelin pamoate. Triptorelin acetate is sold under different brand names, i.e. Decapeptyl®, Pamorelin® or Gonapeptyl® by the companies Ipsen and Ferring. Triptorelin pamoate or embonate, which has a longer acting release form and has been developed by Debiopharm, is commercialized under the brand names Decapeptyl®, Trelstar® and Triptodur® by Ipsen, Verity Pharm and Arbor Pharmaceuticals.

Both salt versions are administrated by intramuscular injection via a pre-filled syringe at different regimens: