Peptide NCEs

With 50 years of expertise in peptides, a track record in process development, large-scale manufacturing and outstanding product quality we are the leading partner in tides.

Bachem’s arsenal of industry-leading talent, cutting-edge equipment and historical legacy enables us to offer a full range of integrated services to bring our partner’s breakthroughs to market.

What Bachem offers

We produce research grade peptides as well as GMP-grade material, from simple peptides to the most complex peptidomimetics or synthetic proteins. Our pipeline of customer peptide NCE projects includes both analytical services and process development:

Analytical services

  • Product characterization
  • Development and validation of analytical methods
  • Stability studies
  • Identification of impurities

Process development, characterization and qualification

  • For all phases of clinical trials
  • Commercial supply

A clear plan for developing the Chemistry, Manufacturing, and Control (CMC), of peptide and oligonucleotide drug substances, affords our partners a risk-mitigated approach to any clinical and commercial milestones. Our interactions with regulatory authorities and sponsors around the world lends itself to a general plan (below), which is custom-tailored to every project.

Innovation is part of our DNA and is more important now than ever, as it’s common to see modified or augmented peptide constructs. Peptides with unnatural amino acids, PEGylation, lipidation, glycosylation, imaging agents and structural constraint, are only a few examples of what we encounter with today’s peptide-based entities.

Bachem strives for innovation by optimizing our supply chain, manufacturing unnatural amino acid derivatives in-house, and meticulous characterization at intermediate stages. We also carefully evaluate peptide synthesis methodology; including liquid phase peptide synthesis, solid phase peptide synthesis, or hybrid approaches.

Modern synthetic innovations like Molecular Hiving™, or downstream innovations like continuous chromatography, and an overall green-conscious process, are examples of pioneering commercial manufacturing technology for peptides, which Bachem is proud to have in our toolbox.

It’s only getting better at Bachem – with a research committee dedicated to evaluating the newest trends and technologies, and collaborating with academic groups and industry non-profits, rest assured that our customers have access to the latest and great in peptides.

The Bachem facilities are regularly inspected and approved by national and international regulatory authorities like FDA, Swissmedic and others and we have available our certificates of GMP compliance, licenses and other documents.

For more insights into the peptide chemistry of Bachem, check out our introduction into the world of amino acids and peptides. For more information on how we synthesize, design and handle peptides, check out our peptide user guide. Both are available on our brochures page.

Our Pipeline

Why choose Bachem?

  • Customer centricity & service – We offer the highest quality products and services in the industry and we stand for trusting and long-standing partnerships. Our customers appreciate our broad knowledge, experience, and expertise in the entire field of development and production of peptides.
  • Innovation and technology – We are passionate about innovation with a strong focus on realizing value in all areas of the company.
  • Operational excellence and quality – The pharmaceutical and biotechnology business requires the most stringent manufacturing standards in the world and demands absolute perfection in quality.
  • People & culture – Our employees make the difference. We are enthusiastic about technology and constant innovation and at the same time proud of our reliability and our solution oriented, hands-on mentality.
  • Sustainability – We are convinced that ethically correct behavior and integrity are essential for long-term business success and therefore continuously monitor and improve our social, economic and environmental performance.

 

What our customers are saying

"Theratechnologies is very pleased to be working with Bachem as a supplier of Tesamorelin. The experience has been very collaborative and contributed to the success of the development program all the way up to market approval. Certainly, Bachem's expertise in peptides, their professional project management and dedication to quality gives us great confidence in knowing we are with the right partner."

- Pierre Perazzelli, V.P. Pharmaceutical Development, Theratechnologies, Inc.

“Bachem is a strategic partner for all Polyphor programs including high quality large scale production of Balixafortide (POL6326) which we are advancing in a Phase III trial in combination with eribulin in patients with advanced breast cancer. Bachem’s collaborative approach with  long term “win-win” business mindset and excellent project management gives us confidence for the future of our programs.”

Gokhan Batur, CEO, Polyphor Ltd

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