White paper

Continuous Chromatography – Pushing the boundaries of peptide and oligonucleotide production

During the manufacturing of an API, well-established purification is crucial for achieving high purity and yield, and at the same time is a major determinant for the cost efficiency and process productivity.

Finding new, innovative methods for improving the efficiency of side-fraction re-purification at large scale means a significant advance in the cost-efficient, fast and sustainable manufacturing of API. At Bachem, we pioneered continuous chromatography at industrial scale to drive capacity, quality and sustainability of the purification process for peptides and oligonucleotides API.

Learn about multicolumn countercurrent solvent gradient purification (MCSGP) in this white paper. MCSGP has shown to achieve substantially higher capacity and yield than single-column batch processes. This innovative purification process leads to time savings, economic advantages and a lower environmental footprint.

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