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March 2016 EDITION

Now available @

Bachem is continuously expanding and updating its extensive range of products for your research purposes. 

We are pleased to present our latest products:

Alzheimer's Disease Related Products
H-8146 Amyloid β-Protein (1-42) TFA Salt
H-7666 FITC-εAhx-Amyloid β-Protein (1-42)
H-7686 (Des-Glu²²)-Amyloid β-Protein (1-42)
The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.
H-7664 Amyloid β-Protein (1-40) amide
H-7662 (Arg¹³)-Amyloid β-Protein (1-40)
H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
H-7728 Amyloid β-Protein (40-1)
Inactive control
H-7656 Amyloid β-Protein (1-24)
H-7672 Amyloid β-Protein (3-40)
H-7668 Amyloid β-Protein (11-42)
Amyloid β-Protein (16-20) amide
Membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis.
Amyloid Precursor Frameshift
Mutant C-Terminal Peptide
The sequence RGRTSSKELA corresponds to human APP frameshift mutant (339-348). RGRTSSKELA is used for generating antibodies.
H-7762 Galanin (human)
Galanin has been shown to inhibit acetylcholine release, glutamate release and carbachol-stimulated phosphatidylinositol hydrolysis in the hippocampus. The peptide hormone is also linked to behavioral and cognitive deficits in Alzheimer's disease.
H-7604 TRAF6 Peptide
The cell-permeable peptide inhibits the interaction of TRAF6, an E3 ubiquitin ligase, with p62 (sequestosome 1). P62 has been shown to be a polyubiquitin shuttling factor which binds to K63-polyubiquitinated proteins. TRAF6-p62 interaction modulators may be used to treat neuropathologies such as Alzheimer's disease or Huntington's disease. For a control peptide see H-7606.
H-7606 TRAF6 Control Peptide
Inactive control for the TRAF6-p62 interaction modulator H-7604, the sequence differs in three positions.
C-4275 1,3-Bis-(Z-Leu-Leu)-diaminoacetone
(Z-LL)₂ Ketone, cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC₅₀ ca. 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasome.

Further Peptides
H-8142 Uroguanylin Topoisomer B (human)

Building Blocks
Cysteine-containing Pseudoproline Dipeptides
Ser and Thr pseudoproline dipeptides play a crucial role in Fmoc-SPPS. The corresponding Cys derivatives broaden the scope of pseudoproline application, especially as cysteine can be desulfurated yielding alanine.
2,4-dimethoxyphenyl(Dmp)-thiaproline is compatible with standard Fmoc/tBu protocols and can be cleaved with 80% TFA in DCM.
B-4365 Fmoc-Ala-Cys(Psi(Me,Me)pro)-OH
B-4395 Fmoc-Gly-Cys(Psi(Dmp,H)pro)-OH
B-4400 Fmoc-Leu-Cys(Psi(Dmp,H)pro)-OH
B-4405 Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)pro)-OH
F-4290 H-β-Cyclohexyl-Ala-OMe · HCl
A-4785 Boc-Cys(StBu)-OH
StBu is cleaved by mercaptans, phosphines and other reducing agents. As it is stable towards TFA it is suitable for Boc-SPPS.
B-4445 Fmoc-Cys(NPys)-OH
Npys allows site-directed disulfide bond formation, as it is cleaved by thiols.
B-4465 Fmoc-His-OMe
B-4505 Fmoc-Lys(palmitoyl-Glu-OtBu)-OH


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Download free N-Methylated Amino Acid Derivatives brochure


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Europe, Africa, Middle East and Asia Pacific:
Bachem AG
Tel: +41 58 595 2020

Bachem Americas, Inc.
Toll Free (USA and Canada): +1 888 422 2436 or Tel: +1 310 539 4171

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All information is compiled to the best of our knowledge. We cannot be made liable for any possible errors or misprints.
Some products may be restricted in certain countries.

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