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Bachem AG Bachem Americas, Inc. Bachem Japan K.K.
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4416 Bubendorf - Switzerland Torrance, CA 90505 - USA 1-9-10 Nihonbashi-Horidome cho, Chuo-ku
Tel +41 58 595 2021 Tel +1 888 422 2436 Tokyo 103-0012 - Japan
Fax +41 58 595 2040 Tel +1 888 4BACHEM Tel +81 3 6661 0774
Email sales.ch@bachem.com Fax +1 310 539 9428 Email sales.jp@bachem.com
  E-mail sales.us@bachem.com  

PEPTIDE TRENDS FEBRUARY 2020

MEET US AT ASIATIDES

AsiaTIDES is the premier event in Asia for accelerating promising oligonucleotide and peptide molecules from research to commercialization. The 2020 edition will take place on February 24 – 26 at the Westin Miyako Kyoto, Kyoto, Japan.

 

AsiaTIDES brings 300+ global oligonucleotide and peptide leaders across Asia, Europe and North America together to present case studies, best practices and to discuss current strategies and trends to accelerate promising molecules to market.

 

Join our presentation at the Main Conference, on Tuesday, February 25, 11:45am - 12:15pm: Dr. Ralph Schönleber, Vice President for Research & Development, Bachem AG, will present «CMC Development Concept for Synthetic Peptides».

 

Bachem‘s pipeline contains more than 150 customer projects in preclinical and clinical phases. In the last couple of years, a number of products in phase III trials received marketing authorization and phase II projects progressed to phase III clinical trials. Starting 2019, Bachem is strategically diversifying its technology platform to include the manufacture of therapeutic oligonucleotides and nucleic-acid-based medicine. A full-service oligonucleotide manufacturing facility is being built at the headquarters in Bubendorf, Switzerland.

 

The Bachem team is excited to meet with you, learn your needs for peptides and oligonucleotides and discuss how Bachem can meet your API custom manufacturing needs. We kindly invite you to drop by our Booth 19 or to contact us  to schedule a meeting in advance.

 

We look forward to meeting you at AsiaTIDES 2020!

BACHEM QUALITY GRADE

Higher standards in documentation and change control are regulatory requirements for cosmetic ingredients and starting materials for cGMP production. We have therefore established the Bachem Quality Grade (BQG).

 

BQG assures batch-to-batch consistency and enables our customers to comply with the current regulatory standards.

 

Our experience makes us the perfect partner for high quality raw and starting materials with comprehensive change and deviation management, ideal for cGMP production and the highly regulated manufacture of cosmetics.

 

We guarantee a stable, long-term supply of amino acid derivatives as well as a sustainable supply of raw materials for cosmetic formulations.

 

 

 

Benefits of the Bachem Quality Grade

 

  • Traceability throughout the complete supply chain
  • Dedicated compliance team responsible for quality management and release
  • Change control for manufacturing processes, analytical methods and for specifications
  • Detailed deviation management
  • Manufacturing according to established processes and using qualified analytical equipment
  • TSE/BSE certificate
  • Purely synthetic processes without usage of GMOs (genetically modified organisms)
  • CMR (carcinogens, mutagens and reprotoxins) free synthesis possible
  • Qualified supply of raw and starting materials
  • Specifications with defined life cycle
  • Validated analytical methods
  • Outstanding purity

 

Partnership

 

In order to provide the best service for your needs, the Bachem Quality Grade captures the requirements of your demand in a quality and supply agreement.

 

A large variety of requirements can be adapted to the needs of our partners.

 

For more information please see our recently released brochures.

 

 

 

 

PEPTIDES FOR ANTI-AGING COSMETICS IN CLINICAL DEVELOPMENT

Peptides have emerged as popular active ingredients in cosmetics in order to help maintain a healthy and youthful appearance. Some peptides affect various cellular and molecular processes within the skin through modulation of collagen, elastin and melanin. In particular, the ability of some synthetic peptides to increase or maintain production of dermal extracellular matrix proteins such as collagen is of interest for anti-aging applications (1). Furthermore, researchers have shown that several peptides have the ability to promote wound healing, cell migration, and angiogenesis. Many peptides are active ingredients in marketed cosmetic products but often there is little in vivo efficacy data known. In addition, cosmetic peptides are often tested as part of a mixture or as a cosmetic formulation limiting knowledge pertaining to the effect of an individual peptide (2). Several examples of cosmetic peptides that have undergone clinical studies to confirm efficacy on human skin are shown in Table 1.

Product Name Category Company
Trifluoroacetyl-tripeptide-2 (Progeline) Signal Peptide Unipex
Tripeptide-10 Citrulline (Decorinyl®) Signal Peptide Lipotec
Palmitoyl Tripeptide (pal-GHK) and pal-GQPR (Matrixyl® 3000) Signal Peptide Croda Personal Care
Copper Tripeptide (GHK-Cu) Carrier Peptide PhotoMedex
Acetylhexapeptide-3 (Argireline®) Neurotransmitter Inhibitor Peptide Lipotec
Pentapeptide-18 (Leuphasyl®) Neurotransmitter Inhibitor Peptide Lipotec
Tripeptide-3 (SYN®-AKE) Neurotransmitter Inhibitor Peptide DSM

Collagen Stimulators

Progeline (Trifluoroacetyl-tripeptide-2) was studied in two in vivo studies. In one study, Progeline was shown to reduce the volume of jawlines after 4 weeks and 8 weeks of treatment. In the second study, the tripeptide improved cutaneous firmness and visco-elasticity. The anti-wrinkle and anti-sagging effects of Progeline treatment were also confirmed by facial macrophotography (3).

Decorinyl® (Tripeptide-10 Citrulline) mimics decorin, a proteoglycan that binds to collagen fibers. This tetrapeptide regulates collagen fibrillogenesis and the growth of collagen fibers making them thinner and uniform. Results from a trial comparing a Decorinyl containing cream to placebo showed an increase of skin suppleness by 54% (4).

Matrixyl® 3000 is an anti-wrinkle peptide mixture containing pal-GHK tripeptide and pal-GQPR tetrapeptide. A clinical study comparing a Matrixyl 3000 containing cream to a placebo cream confirmed anti-wrinkle efficacy and other benefits such as reduction of wrinkle depth, volume and decrease in the area occupied by deep wrinkles (5).

 

Carrier Peptides

Copper Tripeptide (GHK-Cu) is widely used in skin and hair products. This peptide has multiple actions such as stimulating blood vessel and nerve growth. It also increases collagen, elastin and glycosaminoglycan synthesis. The cosmetic benefits of Copper Tripeptide have been confirmed in many clinical studies. In one study, a Copper Tripeptide eye cream applied to photo-damaged eye skin was shown to reduce lines and wrinkles, improve appearance, and increase skin density and thickness (6).

 

Neurotransmitter Inhibitor Peptides

Argireline® (Acetylhexapeptide-3) is a well-known botox-like cosmetic peptide. This peptide is reported to inhibit the release of neurotransmitters and reduce the degree of facial wrinkles. Argireline is the N-terminal end of the synaptosomal nerve-associated protein 25 (SNAP-25) and through competition with the natural protein, the peptide destabilizes the SNARE complex which inhibits release of neurotransmitters and attenuates muscle contraction. In a study of Argireline versus placebo, the anti-wrinkle efficacy in the Argireline treated group was measured at 48.9%, compared with 0% in the placebo group (7).

Leuphasyl® (Pentapeptide-18) is another peptide that has botox-like effects. This peptide mimics enkephalin action, inhibits neuronal activity, and inhibits catecholamine release. In one in vivo study, Leuphasyl was found to have efficacy at a minimum of 2% concentration. In addition, study results showed that the peptide is free from side effects and attenuates wrinkles while also preserving facial expressivity (8).

SYN®-AKE (Tripeptide-3) is a small synthetic peptide that mimics the effect of a peptide found in the venom of the viper Tropidolaemus wagleri. This tripeptide is a reversible antagonist of the muscle-type nicotinic acetylcholine receptor (mnAChR). As a cosmetic active ingredient, it allows the face to relax and smooths out wrinkles. Results from a clinical study showed that SYN-AKE reduced the appearance of wrinkles after 28 days by up to 52% (9).

 

Conclusion

Peptides are a growing area of interest in the field of cosmetics for anti-aging and other personal care applications. While some cosmetic peptides are widely studied and used as active ingredients in the cosmetic industry, clinical studies proving the efficacy of cosmetic peptides are not always published in scientific journals. For researchers and organizations developing peptides for cosmetic applications and studying their efficacy and modes of action, Bachem offers a selection of cosmetic and dermatology peptides. In addition, Bachem offers a comprehensive custom peptide synthesis service.

 

References

(1) B.Reddy et al. Bioactive oligopeptides in dermatology: Part I. Exp. Dermatol. 21(8), 1600-1625 (2012).

(2) S.K.Schagen. Topical peptide treatments with effective anti-aging results. Cosmetics. 4(2), 16 (2017).

(3) E.Long. Trifluoroacetyl-Tripeptide-2 to target senescence for anti-aging benefits. Cosmetics & Toiletries. October 11 (2013).

(4) A.Puig et al. A new decorin-like tetrapeptide for optimal organization of collagen fibres. Int. J. Cosmet. Sci. 30(2), 97-104 (2008).

(5) A.Fournial and P. Mondon. New cosmetic or dermopharmaceutical topical use of a mixture of a GHK tripeptide and GQPR tetrapeptide. International Patent WO 2012/164488 A2. December 6 (2012).

(6) J.Leyden et al. Skin care benefits of copper peptide containing facial cream. Proceedings of the American Academy of Dermatology 60th Annual Meeting, New Orleans, LA, USA. February 22-27 (2002).

(7) Y.Wang et al. The anti-wrinkle efficacy of Argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Am. J. Clin. Dermatol. 14(2), 147-153 (2013).

(8) A.O.Dragomirescu et al. The efficiency and safety of Leuphasyl-A botox-like peptide. Cosmetics. 1, 75-81 (2014).

(9) M.N.Zhmak et al. Peptide inhibitors of nicotinic acetylcholine receptor. US Patent 9,550,808 B2. January 24 (2017).

MEET BACHEM: JIMMY NAZARETH, MARKET ANALYST

PT: What is your official job title at Bachem?

Jimmy: My official job title is Market Analyst.

 

PT: How long have you been with Bachem? Where did you work before Bachem?

Jimmy: I am with Bachem since September 2019. Before joining Bachem, I worked in the Marketing & Sales department as a Business Analyst for a large chemical company in Switzerland.

 

PT: Briefly, what do you do at Bachem?

Jimmy: I focus on Business Intelligence and Competitive Intelligence. I evaluate data, as well as competitor and industry data, to discover ways to improve Bachem’s market position.

 

PT: What is your academic background/degrees or training?

Jimmy: I hold both a Bachelor and a Master degree in business management.

 

PT: What do you like to do outside of work?

Jimmy: I enjoy spending time with family and friends. It is a great way to socialize and to stay motivated by encouraging each other.

 

PT: How is the Marketing & Sales team partnering with their customers?

Jimmy: Steady communication with customers helps to gain better understanding of their requirements, and overall make customers feel valued and important.

 

PT: What makes a perfect day for you?

Jimmy: A perfect day is waking up with determination, feeling energized.

 

PT: What is your business motto?

Jimmy: Recognition and open appreciation are highly motivating.

 

PT: What do you like most about your job?

Jimmy: The chance to be in both worlds, business and technology. Collaborate and managing relationship with both colleagues and vendors from all around the world.

 

PT: Have you had any particular expectation when you came to Bachem and have these been fulfilled?

Jimmy: Good working atmosphere and competent team members were my expectations and these have been fulfilled.

 

PT: What is your preferred peptide?

Jimmy: Proteins are essential parts of organisms and therefore I like all peptides.

 

PT: Thank you very much Jimmy.

PEPTIDE HIGHLIGHTS

LITERATURE CITATIONS

Bachem peptides and biochemicals are widely cited in research publications. Congratulations to all our customers with recent publications!

 

J.Fraczyk et al.

Conjugates of copper alginate with arginine-glycine-aspartic acid (RGD) for potential use in regenerative medicine.

Materials (Basel) 13, (2020)

 

T.T.Asai et al.

Food-derived collagen peptides, prolyl-hydroxyproline (Pro-Hyp), and hydroxyprolyl-glycine (Hyp-Gly) enhance growth of primary cultured mouse skin fibroblast using fetal bovine serum free from hydroxyprolyl peptide.

International Journal of Molecular Sciences 21, (2019)

 

A.J.Kleinnijenhuis et al.

Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption.

Analytical and Bioanalytical Chemistry (2019)

 

Z.Liu et al.

Collagen peptides promote photoaging skin cell repair by activating the TGF-β/Smad pathway and depressing collagen degradation.

Food & Function 10, 6121-6134 (2019)