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In this section you can find our recently published scientific articles in the field of peptide research and peptide synthesis.

Please visit our
literature archive for more of our contributions in the area of peptide research and peptide synthesis.


D.Samson, D.Rentsch, M.Minuth, T.Meier and G.Loidl
The aspartimide problem persists: Fluorenylmethyloxycarbonyl-solid-phase peptide synthesis (Fmoc-SPPS) chain termination due to formation of N-terminal piperazine-2,5-diones.
J. Pept. Sci. 25, e3193 (2019)


S.Eissler, M.Kley, D.Bächle, G.Loidl, T.Meier, and D.Samson
Substitution determination of Fmoc-substituted resins at different wavelengths
J. Pept. Sci., 23, 757-762 (2017)


B.Dhayalan, K.Mandal, N.Rege, M.A.Weiss, S.H.Eitel, T.Meier, R.O.Schoenleber, and S.B.Kent
Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin
Chem. Eur. J.23(7),1709-1716 (2017)


Ch.McGee and J.Thundimadathil
Chemical Glycosylation of Peptides
Pharma Horizon 1(2) (2017)


A.Gangakhedkar and J.Thundimadathil
Review: Glucagon-Like Peptide 1 (GLP-1) in the Treatment of Diabetes / GLP-1 Agonist Peptides against Type 2 Diabetes Are Promising Targets for Patients with Poor Hb1Ac Control
Genetic Engineering & Biotechnology News35(13) (2015)


M.Mergler, G.Loidl, M.Diekmann, and F.Dick
Bachem - Insights into Peptide Chemistry Achievements by the World's Leading Independent Manufacturer of Peptides
Chimia67, 874-880 (2013)

D.Rentsch, C.Stahelin, M.Obkircher, R.Hany, M.Simeunovic, D.Samson, G.Loidl, and F.Dick
Quantitative assessment of preloaded 4-alkoxybenzyl alcohol resins for solid-phase peptide syntheses by 1D and 2D HR-MAS NMR
ACS Comb. Sci. 14, 613-620 (2012)

C.Beeton, M.W.Pennington and R.S.Norton
Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases
Inflamm. Allergy Drug Targets 10, 313-321 (2011)

S.S.Chauhan and H.J.Wilk
Efficient stereocontrolled synthesis of (S)-Fmoc-β-nitroalanine via oxidation of oxime
Tetrahedron Lett. 51, 3340-3343 (2010)

Recent developments to encourage the synthesis of complex peptides
PharmaChem 9 (3/4), 19-23 (2010)

Critical parameters for solid-phase manufacturing of therapeutic peptides
Chim. Oggi 28, 22-25 (2010)

S.Rangaraju, K.K.Khoo, Z.-P.Feng, G.Crossley, D.Nugent, I.Khaytin, V.Chi, C.Pham, P.Calabresi, M.W.Pennington, R.S.Norton and K.G.Chandy
Potassium channel modulation by a toxin domain in matrix metalloprotease 23
J. Biol. Chem. 285, 9124-9136 (2010)

Enantioselective synthesis of (L)-Fmoc-α-Me-Lys(Boc)-OH via diastereoselective alkylation of oxazinone as a chiral auxiliary
Tetrahedron Lett. 50, 6913-6915 (2009)

M.W.Pennington, C.Beeton, C.A.Galea, B.J.Smith, V.Chi, K.P.Monaghan, A.Garcia, S.Rangaraju, A.Giuffrida, D.Plank, G.Crossley, D.Nugent, I.Khaytin, Y.LeFievre, I.Peshenko, C.Dixon, S.Chauhan, A.Orzel, T.Inoue, X.Hu, R.V.Moore, R.S.Norton and K.G.Chandy
Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes
Mol. Pharmacol. 75, 762–773 (2009)

Peptides as drugs - Molecular evolvement in recent years
PharmaChem 7 (9), 13-16 (2008)

M.Vaara, J.Fox, G.Loidl, O.Siikanen, J.Apajalahti, F.Hansen, N.Frimodt-Møller, J.Nagai, M.Takano and T.Vaara
Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents
Antimicrob. Agents Chemother. 52, 3229-3236 (2008)

M.P.Matheu, C.Beeton, A.Garcia, V.Chi, S.Rangaraju, O.Safrina, K.Monaghan, M.I.Uemura, D.Li, S.Pal, la Maza, E.Monuki, A.Flügel, M.W.Pennington, I.Parker, K.G.Chandy and M.D.Cahalan
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block
Immunity 29, 1-13 (2008)

M.Obkircher, C.Stähelin and F.Dick
Formation of Fmoc-β-alanine during Fmoc-protections with Fmoc-OSu
J. Pept. Sci. 14, 763-766 (2008)

C.Beeton, B.J.Smith, J.K.Sabo, G.Crossley, D.Nugent, I.Khaytin, V.Chi, K.G.Chandy, M.W.Pennington and R.S.Norton
The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation
J. Biol. Chem. 283, 988-997 (2008)

H.Wulff and M.Pennington
Targeting effector memory T-cells with Kv1.3 blockers
Curr. Opin. Drug Discov. Devel. 10, 438-445 (2007)

J.A.Durr, M.Blankenship, S.S.Chauhan and M.W.Pennington
Targeted tyrosine iodination in a multi-tyrosine vasopressin analog
J. Pept. Sci. 13, 756-761 (2007)

L.Hu, M.Pennington, Q.Jiang, K.A.Whartenby and P.A.Calabresi
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes
J. Immunol. 179, 4563-4570 (2007)

F.Dick, M.Mergler, G.Loidl, R.Schönleber and T.Vorherr
Purification of sparingly soluble peptides by temporary solubilization
Proceedings of the 29th European Peptide Symposium, Gdansk (2006). Kenes International, Switzerland (2007)

S.Chauhan, A.Varshney, B.Verma and M.W.Pennington
Efficient synthesis of protected L-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis
Tetrahedron Lett.. 48, 4051-4054 (2007)

Purification: The bottleneck in peptide production
Spec. Chem. 27, 40-42 (2007)

Approaches for the purification of sparingly soluble peptides
Chim. Oggi 25, 22-24 (2007)

C.Beeton, H.Wulff, N.E.Standifer, P.Azam, K.M.Mullen, M.W.Pennington, A.Kolski-Andreaco, E.Wei, A.Grino, D.R.Counts, P.H.Wang, C.J.LeeHealey, B.S.Andrews, A.Sankaranarayanan, D.Homerick, W.W.Roeck, J.Tehranzadeh, K.L.Stanhope, P.Zimin, P.J.Havel, S.Griffey, H.-G.Knaus, G.T.Nepom, G.A.Gutman, P.A.Calabresi and K.G.Chandy
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
Proc. Natl. Acad. Sci. USA 103, 17414–17419 (2006)

K.M.Mullen, M.Rozycka, H.Rus, L.Hu, C.Cudrici, E.Zafranskaia, M.W.Pennington, D.C.Johns, S.I.V.Judge and P.A.Calabresi
Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system
Ann. Neurol. 60, 118–127 (2006)

Peptides: Impact of new technologies on chemical production
PharmaChem 5 (7/8), 14-17 (2006)

T.Kawakami, M.Sumida, K.Nakamura, T.Vorherr and S.Aimoto
Peptide thioester preparation based on an N-S acyl shift reaction mediated by a thiol ligation auxiliary
Tetrahedron Lett. 46, 8805-8807 (2005)

M.Mergler and F.Dick
The aspartimide problem in Fmoc-based SPPS. Part III
J. Pept. Sci.11, 650-657 (2005)

T.Vorherr, F.Dick and B.Sax
Bachem, a Swiss speciality cGMP-manufacturer:
History and future prospects

Chimia 59, 25-27 (2005)

S.Singh, G.Crossley, S.Ghosal, Y.Lefievre and M.Pennington
A short practical synthesis of 2'-deoxymugineic acid
Tetrahedron Lett. 46, 1419-1421 (2005)

C.Beeton, M.W.Pennington, H.Wulff, S.Singh, D.Nugent, G.Crossley, I.Khaytin, P.A.Calabresi, C.Chen, G.A.Gutman and K.G.Chandy
Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
Mol. Pharmacol. 67, 1369-1981 (2005)

X.Lauth, J.J.Babon, J.A.Stannard, S.Singh, V.Nizet, J.M.Carlberg, V.E.Ostland, M.W.Pennington, R.S.Norton and M.E.Westerman
Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections
J. Biol. Chem. 280, 9272-9282 (2005)

R.S.Norton, M.W.Pennington and H.Wulff
Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases
Curr. Med. Chem. 11, 3141-3152 (2004)

Asymmetric synthesis of (R)- and (S)-a-methylcysteine
Recent Res. Devel. Organic Chem. 8, 323-339 (2004)

H.Wulff, H.G.Knaus, M.Pennington and K.G.Chandy
K+ Channel expression during B cell differentiation:
Implications for immunomodulation and autoimmunity

J. Immunol. 173, 776-786 (2004)

S.Singh, S.J.Rao and M.W.Pennington
Efficient asymmetric synthesis of (S)- and (R)-N-Fmoc-S-Trityl-a-methylcysteine using camphorsultam as a chiral auxiliary
J. Org. Chem. 69, 4551-4554 (2004)

K.G.Chandy, H.Wulff, C.Beeton, M.Pennington, G.A.Gutman and M.D.Cahalan
K+ channels as targets for specific immunomodulation
Trends Pharmacol. Sci. 25, 280-289 (2004)

S.F.Brady, S.Singh, M.C.Crouthamel, M.K.Holloway, C.A.Coburn, V.M.Garsky, M.Bogusky, M.W.Pennington, J.P.Vacca, D.Hazuda and M.T.Lai
Rational design and synthesis of selective BACE-1 inhibitors
Bioorg. Med. Chem. Lett. 14, 601-604 (2004)