Topic: Solid Phase Synthesis

21 September 2026

Case study: Scale siRNA manufacturing efficiently via a fragment and enzymatic ligation approach

As demand for siRNA therapeutics continues to grow, manufacturers face increasing pressure to deliver larger quantities of drug…

11 June 2026

Stirring Things Up: Integrating Stirred-Bed SPOS and Enzymatic Ligation for Industrial Oligonucleotide Production

    The rising demands for therapeutic oligonucleotides requires scalable, efficient, and more sustainable manufacturing solutions. Stirred bed…

20 April 2026

GLP-1 Demand: What it means for peptide manufacturers

GLP-1 receptor agonists are transforming peptide manufacturing. For decades, peptide APIs were typically produced at kilogram scale for…

30 March 2026

Linear vs Fragment SPPS for Peptide Manufacturing

As demand for complex peptide APIs reaches unprecedented scales, manufacturers face a critical strategic question: is linear solid-phase…

18 February 2026

Webinar Evaluation of linear SPPS vs. conjugation of SPPS-based fragments

About the webinar As demand for peptide-based APIs grows, selecting the most efficient and cost-effective manufacturing route is critical.…

09 January 2026

Publications

Review the scientific articles where the Bachem team has contributed to peptide and oligonucleotide research. Symmetrical Branching Unit…

16 October 2024

Improving Oligonucleotide manufacture with stirred bed technology

Oligonucleotide-based active pharmaceutical ingredients (APIs) have emerged as a powerful approach to treating diseases. With hundreds of them…