Evaluation of Linear SPPS vs. Conjugation of SPPS-based Fragments

As demand for peptide-based APIs grows, selecting the most efficient and cost-effective manufacturing route is critical. This presentation compares linear Solid-Phase Peptide Synthesis (SPPS) with SPPS-based fragment conjugation, focusing on cost and scalability in large-scale production. Through a case study, modeling assumptions, experimental setups, and key efficiency parameters will be explored to guide informed decisions in optimizing peptide API manufacturing strategies.

About the Speaker

Pascal Engi, PhD

Senior Group Leader R&D

Pascal Engi studied chemistry at the University of Bern, Switzerland. He then joined the group of Prof. Florian Seebeck at the University of Basel, where he obtained his Ph.D. for designing and synthesizing modified peptide and amino acid probes to elucidate enzymatic mechanisms in 2017. In 2018 he started his career as project chemist with Bachem in Switzerland. Pascal took a position as team leader in the R&D department after a short while and later as senior group leader in the same department. During his time at Bachem, he has been involved with many successful and challenging process development projects as well as GMP and non-GMP manufacturing campaigns.

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