IOPC 2022
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IOPC 2022
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Purification of synthetic oligonucleotides using continuous chromatography (MCSGP)
by Ralf Eisenhuth, Process Manager Chromatography and Technology Transfer Oligo
With oligonucleotides moving out of the orphan drug niche, there is an observable trend to larger drug substance volumes. Only application of new technologies will allow sustainable manufacturing of such large volumes. MCSGP is a breakthrough technology for purification that can be applied for anion exchange (AEX) or hydrophobic interaction chromatography (HIC). Its application for the AEX purification of a synthetic oligonucleotide will be discussed in case study comprising method development and manufacturing of a small batch.
DAY ONE: Tuesday, June 28, Oligonucleotides Session, 3-3:20 pm