Knowledge Hub 
Knowledge Hub
Case study: Scale siRNA manufacturing efficiently via a fragment and enzymatic ligation approach
As demand for siRNA therapeutics continues to grow, manufacturers face increasing pressure to deliver larger quantities of drug…
Different types of liquid chromatography explained
Liquid chromatography is one of the most widely used analytical techniques in pharmaceutical development. Almost every modern drug…
Case study: Verification of SAX method selectivity using 2D-LC-MS for peak purity assessment of oligonucleotide APIs
Accurate analytical characterization is essential throughout oligonucleotide development, supporting impurity profiling, stability assessment, and ultimately the delivery of…
API contract manufacturing: Process, benefits, and partner selection
Manufacturing active pharmaceutical ingredients (APIs) is a complex undertaking that requires specialized process knowledge, advanced manufacturing capabilities, and…
What is Tag-Assisted Peptide Synthesis (TAPS)?
As the leading peptide manufacturer, Bachem is at the forefront of innovative synthesis methods. One cutting-edge approach is…
Stirring Things Up: Integrating Stirred-Bed SPOS and Enzymatic Ligation for Industrial Oligonucleotide Production
The rising demands for therapeutic oligonucleotides requires scalable, efficient, and more sustainable manufacturing solutions. Stirred bed…